FOG16091
EOG898SGG

sce:UGO1

Genes: 32

SGD Description
Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter


PomBase Description
mitochondrial fusion protein Ugo1 (predicted)


AspGD Description
Ortholog(s) have role in mitochondrial fusion and integral component of mitochondrial outer membrane localization


References

Belenkiy R, et al. (2000 Jul 31). The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins.

Sesaki H, et al. (2001 Mar 19). UGO1 encodes an outer membrane protein required for mitochondrial fusion.

Wong ED, et al. (2003 Feb 3). The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion.

Sesaki H, et al. (2003 Jun). Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Sesaki H, et al. (2004 Jul 2). Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%