FOG15996
EOG89GJ2H

sce:MIA40

Genes: 33

SGD Description
Mitochondrial oxidoreductase; involved in mitochondrial intermembrane space import; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro


PomBase Description
TIM22 inner membrane protein import complex subunit Tim40 (predicted)


AspGD Description
Protein of unknown function


References

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Naoé M, et al. (2004 Nov 12). Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space.

Chacinska A, et al. (2004 Oct 1). Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins.

Terziyska N, et al. (2005 Jan 3). Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions.

Mesecke N, et al. (2005 Jul 1). A disulfide relay system in the intermembrane space of mitochondria that mediates protein import.

Rissler M, et al. (2005 Oct 28). The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins.

Zahedi RP, et al. (2006 Mar). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.

Kawano S, et al. (2009 Aug 25). Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space.

von der Malsburg K, et al. (2011 Oct 18). Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 17 genes with posterior transmembrane prediction > 50%