FOG15784
EOG8B2RF6

sce:DIA2

Genes: 18

SGD Description
Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitylation of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth


References

Willems AR, et al. (1999 Sep 29). SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis.

Palecek SP, et al. (2000 Nov). Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae.

Bao MZ, et al. (2004 Dec 29). Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.

Kus BM, et al. (2004 Feb 15). Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro.

Serrano R, et al. (2004 May 7). Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment.

Sarin S, et al. (2004 Nov). Uncovering novel cell cycle players through the inactivation of securin in budding yeast.

Koepp DM, et al. (2006 Apr). The F-box protein Dia2 regulates DNA replication.

Pan X, et al. (2006 Mar 10). A DNA integrity network in the yeast Saccharomyces cerevisiae.

Morohashi H, et al. (2009 Dec 1). The amino-terminal TPR domain of Dia2 tethers SCF(Dia2) to the replisome progression complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%