FOG15781
EOG8B2RFR

sce:PUP1

Genes: 33

SGD Description
Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z


PomBase Description
20S proteasome complex subunit beta 2 (predicted)


AspGD Description
Ortholog(s) have endopeptidase activity and role in proteasomal ubiquitin-independent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process


References

Haffter P, et al. (1991 Sep 25). Nucleotide sequence of PUP1 encoding a putative proteasome subunit in Saccharomyces cerevisiae.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Bohn S, et al. (2010 Dec 7). Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Penney M, et al. (2012). Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%