FOG15473
EOG8BVQBB

sce:STP22

Genes: 24

SGD Description
Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype;


AspGD Description
Ortholog(s) have ubiquitin binding activity and role in late endosome to vacuole transport, negative regulation of protein polyubiquitination, protein targeting to membrane, protein targeting to vacuole


References

Li Y, et al. (1999 May). Yeast mutants affecting possible quality control of plasma membrane proteins.

Babst M, et al. (2000 Mar). Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking.

Katzmann DJ, et al. (2001 Jul 27). Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

Brachat S, et al. (2003). Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.

Katzmann DJ, et al. (2003 Aug 4). Vps27 recruits ESCRT machinery to endosomes during MVB sorting.

Teo H, et al. (2004 Jul 2). Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.

Bowers K, et al. (2004 Mar). Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

Kostelansky MS, et al. (2006 Apr 7). Structural and functional organization of the ESCRT-I trafficking complex.

Teo H, et al. (2006 Apr 7). ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.

Gill DJ, et al. (2007 Jan 24). Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.

Kostelansky MS, et al. (2007 May 4). Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%