FOG15236
EOG8CFXQZ

sce:MID1

Genes: 32

SGD Description
N-glycosylated integral membrane protein of the ER and plasma membrane; functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer


PomBase Description
stretch-activated calcium ion channel Yam8


AspGD Description
Stretch-activated Ca2+ channel family protein


References

Iida H, et al. (1994 Dec). MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating.

Kanzaki M, et al. (1999 Aug 6). Molecular identification of a eukaryotic, stretch-activated nonselective cation channel.

Tasaka Y, et al. (2000 Mar 5). yam8(+), a Schizosaccharomyces pombe gene, is a potential homologue of the Saccharomyces cerevisiae MID1 gene encoding a stretch-activated Ca(2+)-permeable channel.

Carnero E, et al. (2000 Sep). Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall integrity and in calcium uptake.

Locke EG, et al. (2000 Sep). A homolog of voltage-gated Ca(2+) channels stimulated by depletion of secretory Ca(2+) in yeast.

Maruoka T, et al. (2002 Apr 5). Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1.

De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.

Yoshimura H, et al. (2004 Feb 15). Subcellular localization and oligomeric structure of the yeast putative stretch-activated Ca2+ channel component Mid1.

Tada T, et al. (2004 Jan 16). Phe356 in the yeast Ca2+ channel component Mid1 is a key residue for viability after exposure to alpha-factor.

Ozeki-Miyawaki C, et al. (2005 Nov 15). Identification of functional domains of Mid1, a stretch-activated channel component, necessary for localization to the plasma membrane and Ca2+ permeation.

Peiter E, et al. (2005 Oct 24). The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity.

Chikashige Y, et al. (2006 Apr 7). Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Deng L, et al. (2006 Nov). Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeast.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Bencina M, et al. (2009 Mar). A comparative genomic analysis of calcium and proton signaling/homeostasis in Aspergillus species.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.

Hamasaki-Katagiri N, et al. (2010 Feb 12). Neuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast.

Ma Y, et al. (2011). Transient receptor potential (TRP) and Cch1-Yam8 channels play key roles in the regulation of cytoplasmic Ca2+ in fission yeast.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Gao L, et al. (2011 Nov). Osmotic stabilizer-coupled suppression of NDR defects is dependent on the calcium-calcineurin signaling cascade in Aspergillus nidulans.

Wang S, et al. (2012). Putative calcium channels CchA and MidA play the important roles in conidiation, hyphal polarity and cell wall components in Aspergillus nidulans.

Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhang S, et al. (2014 Feb). FigA, a putative homolog of low-affinity calcium system member Fig1 in Saccharomyces cerevisiae, is involved in growth and asexual and sexual development in Aspergillus nidulans.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 18 genes with posterior transmembrane prediction > 50%