FOG15235
EOG8CFXR2

sce:ICP55

Genes: 33

SGD Description
Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family


PomBase Description
mitochondrial intermediate cleavage peptidase Icp55 (predicted)


AspGD Description
Ortholog(s) have aminopeptidase activity, role in protein processing, protein stabilization and extrinsic component of mitochondrial inner membrane, nucleus localization


References

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Vögtle FN, et al. (2009 Oct 16). Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.

Naamati A, et al. (2009 Oct 30). Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.

Fontebasso Y, et al. (2013 Dec). The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%