FOG15005
EOG8D254Z

sce:FZO1

Genes: 34

SGD Description
Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system


PomBase Description
mitochondrial dynamin family fusion GTPase protein (predicted)


AspGD Description
Ortholog(s) have GTPase activity, protein homodimerization activity, role in mitochondrial fusion, mitochondrion localization and integral component of mitochondrial outer membrane, mitochondrial inner membrane localization


References

Rapaport D, et al. (1998 Aug 7). Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae.

Hermann GJ, et al. (1998 Oct 19). Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p.

Sesaki H, et al. (1999 Nov 15). Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape.

Fritz S, et al. (2001 Feb 19). Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion.

Sesaki H, et al. (2003 Jun). Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane.

Sesaki H, et al. (2004 Jul 2). Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion.

Meeusen S, et al. (2004 Sep 17). Mitochondrial fusion intermediates revealed in vitro.

Neutzner A, et al. (2005 May 13). Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae.

Griffin EE, et al. (2006 Jun 16). Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion.

Escobar-Henriques M, et al. (2006 Jun 5). Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1.

Cohen MM, et al. (2008 Jun). Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion.

Amiott EA, et al. (2009 Dec). A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover.

Palermo V, et al. (2010 Aug). Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission.

Hammermeister M, et al. (2010 Jul 15). Mdm36 is a mitochondrial fission-promoting protein in Saccharomyces cerevisiae.

Anton F, et al. (2011 Apr 1). Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion.

Cohen MM, et al. (2011 May 1). Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion.

Fernández-Cid A, et al. (2012 May). Glucose levels regulate the nucleo-mitochondrial distribution of Mig2.

Anton F, et al. (2013 Feb 7). Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways.

Brandt T, et al. (2016 Jun 2). A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%