FOG14452
EOG8FFBK8

sce:NCS6

Genes: 33

SGD Description
Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae


PomBase Description
cytosolic thiouridylase subunit Ctu1


AspGD Description
Ortholog(s) have tRNA binding activity and role in protein urmylation, regulation of cell shape, regulation of translational fidelity, tRNA wobble position uridine thiolation


References

Kail M, et al. (1996 Jun 30). Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames.

Brachat S, et al. (2003). Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.

Goehring AS, et al. (2003 Nov). Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast.

Björk GR, et al. (2007 Aug). A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.

Johansson MJ, et al. (2008 May). Eukaryotic wobble uridine modifications promote a functionally redundant decoding system.

Huang B, et al. (2008 Oct). A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae.

Nakai Y, et al. (2008 Oct 10). Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems.

Noma A, et al. (2009 Mar). Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions.

Leidel S, et al. (2009 Mar 12). Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%