FOG14276
EOG8FXPPF

sce:HRQ1

Genes: 33

SGD Description
3'-5' DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; acts with Rad4p in nucleotide-excision repair; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome (RTS)


PomBase Description
RecQ type DNA helicase Hrq1 (predicted)


AspGD Description
Ortholog(s) have ATP-dependent 3'-5' DNA helicase activity, bubble DNA binding activity


References

Shiratori A, et al. (1999 Feb). Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis.

Barea F, et al. (2008 Oct). In silico analyses of a new group of fungal and plant RecQ4-homologous proteins.

Kwon SH, et al. (2012 Oct 26). Saccharomyces cerevisiae Hrq1 requires a long 3'-tailed DNA substrate for helicase activity.

Choi DH, et al. (2013 Feb). Hrq1 functions independently of Sgs1 to preserve genome integrity in Saccharomyces cerevisiae.

Choi DH, et al. (2014 Apr). Hrq1 facilitates nucleotide excision repair of DNA damage induced by 4-nitroquinoline-1-oxide and cisplatin in Saccharomyces cerevisiae.

Leung GP, et al. (2014 Apr 2). Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae.

Bochman ML, et al. (2014 Jan 30). Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 10 genes with posterior transmembrane prediction > 50%