FOG14275
EOG8FXPPX

sce:DNL4

Genes: 30

SGD Description
DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome


PomBase Description
DNA repair ligase Lig4


AspGD Description
Ortholog(s) have role in DNA recombination


References

Andaluz E, et al. (1996 Jul). A Candida albicans gene encoding a DNA ligase.

Ramos W, et al. (1997 Apr 15). Two distinct DNA ligase activities in mitotic extracts of the yeast Saccharomyces cerevisiae.

Herrmann G, et al. (1998 Jul 15). Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4.

Andaluz E, et al. (1999 Sep 15). Cell cycle regulation of a DNA ligase-encoding gene (CaLIG4) from Candida albicans.

Andaluz E, et al. (2001 Jan). Phenotypic analysis and virulence of Candida albicans LIG4 mutants.

Andaluz E, et al. (2002 Aug). An evaluation of the role of LIG4 in genomic instability and adaptive mutagenesis in Candida albicans.

Tseng HM, et al. (2002 Nov 22). A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining.

Doré AS, et al. (2006 Mar 7). Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%