FOG13703
EOG8HDR9G

sce:RAD3

Genes: 32

SGD Description
5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress


PomBase Description
transcription factor TFIIH complex subunit Rad15


AspGD Description
Ortholog(s) have ATP-dependent 5'-3' DNA helicase activity, damaged DNA binding activity


References

Reynolds P, et al. (1985 Apr 11). The nucleotide sequence of the RAD3 gene of Saccharomyces cerevisiae: a potential adenine nucleotide binding amino acid sequence and a nonessential acidic carboxyl terminal region.

Naumovski L, et al. (1985 Jan). RAD3 gene of Saccharomyces cerevisiae: nucleotide sequence of wild-type and mutant alleles, transcript mapping, and aspects of gene regulation.

Sung P, et al. (1988 Oct). Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP.

Song JM, et al. (1990 Dec). Effects of multiple yeast rad3 mutant alleles on UV sensitivity, mutability, and mitotic recombination.

Bailly V, et al. (1991 Nov 1). DNA.RNA helicase activity of RAD3 protein of Saccharomyces cerevisiae.

Harosh I, et al. (1991 Nov 25). The RAD3 gene is a member of the DEAH family RNA helicase-like protein.

Feaver WJ, et al. (1993 Dec 31). Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair.

Deschavanne PJ, et al. (1993 Mar). The Rad3 protein from Saccharomyces cerevisiae: a DNA and DNA:RNA helicase with putative RNA helicase activity.

Svejstrup JQ, et al. (1994 Nov 11). RNA polymerase transcription factor IIH holoenzyme from yeast.

Sung P, et al. (1996 May 3). Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repair.

Takagi Y, et al. (2003 Nov 7). Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Rudolf J, et al. (2006 Sep 15). The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%