FOG13548
EOG8HT77P

sce:CNA1;CMP2

Genes: 44

SGD Description
Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication|Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication


PomBase Description
calcium-dependent serine/threonine protein phosphatase calcineurin A, catalytic subunit Ppb1


AspGD Description
Ortholog(s) have calcium-dependent protein serine/threonine phosphatase activity


References

da Cruz e Silva EF, et al. (1989 Dec 22). Isolation of a cDNA likely to encode a novel Ca2+-dependent/calmodulin-stimulated protein phosphatase.

Cyert MS, et al. (1991 Aug 15). Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

Liu Y, et al. (1991 May). The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B.

Ye RR, et al. (1992 Mar 1). Identification and molecular characterization of the calmodulin-binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae. An alpha-factor inducible gene.

Rasmussen C, et al. (1994 Aug 15). The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.

Nanthakumar NN, et al. (1996). Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.

Juvvadi PR, et al. (2001 Oct 16). Cloning and sequence analysis of cnaA gene encoding the catalytic subunit of calcineurin from Aspergillus oryzae.

Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.

Soriani FM, et al. (2008 Mar). Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA.

Son S, et al. (2009 Apr). Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Soriani FM, et al. (2010 Jan 15). Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA.

Gao L, et al. (2011 Nov). Osmotic stabilizer-coupled suppression of NDR defects is dependent on the calcium-calcineurin signaling cascade in Aspergillus nidulans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Colabardini AC, et al. (2014). Protein kinase C overexpression suppresses calcineurin-associated defects in Aspergillus nidulans and is involved in mitochondrial function.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%