FOG12588
EOG8M63ZC

sce:LTE1

Genes: 32

SGD Description
Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures


AspGD Description
Has domain(s) with predicted guanyl-nucleotide exchange factor activity, role in regulation of small GTPase mediated signal transduction, small GTPase mediated signal transduction and intracellular localization


References

Wickner RB, et al. (1987 Mar). Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation of the MAK16 gene and analysis of an adjacent gene essential for growth at low temperatures.

Wickner RB, et al. (1988 Aug). Host function of MAK16: G1 arrest by a mak16 mutant of Saccharomyces cerevisiae.

Shirayama M, et al. (1994 Apr). Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1.

Keng T, et al. (1994 Jul). LTE1 of Saccharomyces cerevisiae is a 1435 codon open reading frame that has sequence similarities to guanine nucleotide releasing factors.

Shirayama M, et al. (1994 Nov). The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase.

Shou W, et al. (1999 Apr 16). Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex.

Gruneberg U, et al. (2000 Dec 1). Nud1p links astral microtubule organization and the control of exit from mitosis.

Bardin AJ, et al. (2000 Jul 7). A mechanism for coupling exit from mitosis to partitioning of the nucleus.

Adames NR, et al. (2001 Apr 2). The surveillance mechanism of the spindle position checkpoint in yeast.

Lee SE, et al. (2001 Jun). The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis.

Jensen S, et al. (2002 Dec 15). Spatial regulation of the guanine nucleotide exchange factor Lte1 in Saccharomyces cerevisiae.

Seshan A, et al. (2002 Dec 23). Control of Lte1 localization by cell polarity determinants and Cdc14.

Höfken T, et al. (2002 Sep 16). A role for cell polarity proteins in mitotic exit.

Castillon GA, et al. (2003 Apr 15). Septins have a dual role in controlling mitotic exit in budding yeast.

Yoshida S, et al. (2003 Jun 9). Ras recruits mitotic exit regulator Lte1 to the bud cortex in budding yeast.

Molk JN, et al. (2004 Apr). The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit.

Jensen S, et al. (2004 Jun). Temporal coupling of spindle disassembly and cytokinesis is disrupted by deletion of LTE1 in budding yeast.

Zhao X, et al. (2007 Jan 19). A role for Lte1p (a low temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%