FOG12330
EOG8MSBGW

sce:GDT1

Genes: 35

SGD Description
Protein of unknown function involved in calcium homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant


PomBase Description
human TMEM165 homolog, implicated in calcium tranport|human TMEM165 homolog, implicated in calcium transport


AspGD Description
Ortholog(s) have role in cellular calcium ion homeostasis, hyphal growth and Golgi medial cisterna, cis-Golgi network, endoplasmic reticulum, fungal-type vacuole membrane localization


References

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Barbara KE, et al. (2007 Feb). The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level.

Demaegd D, et al. (2013 Apr 23). Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells.

Rosnoblet C, et al. (2013 Jul 15). Impact of disease-causing mutations on TMEM165 subcellular localization, a recently identified protein involved in CDG-II.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Colinet AS, et al. (2016 Apr 14). Yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signaling and protein glycosylation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 35 genes with posterior transmembrane prediction > 50%