FOG12329
EOG8MSBHH

sce:CGI121

Genes: 30

SGD Description
Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p


PomBase Description
EKC/KEOPS complex subunit Cgi121 (predicted)


AspGD Description
Ortholog(s) have role in positive regulation of transcription from RNA polymerase II promoter, regulation of cell aging, telomere maintenance via recombination and EKC/KEOPS complex, cytosol, nucleus localization


References

Kisseleva-Romanova E, et al. (2006 Aug 9). Yeast homolog of a cancer-testis antigen defines a new transcription complex.

Downey M, et al. (2006 Mar 24). A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.

Miura F, et al. (2006 Nov 21). A large-scale full-length cDNA analysis to explore the budding yeast transcriptome.

Juneau K, et al. (2007 Jan 30). High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing.

Daugeron MC, et al. (2011 Aug). Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs.

Srinivasan M, et al. (2011 Mar 2). The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.

Perrochia L, et al. (2013 Feb 1). In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya.

Wan LC, et al. (2013 Jul). Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Zhou H, et al. (2015 Oct). Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%