FOG12118
EOG8NCJTK

sce:ATG11

Genes: 21

SGD Description
Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy


References

Harding TM, et al. (1996 Jul 26). Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway.

Kamada Y, et al. (2000 Sep 18). Tor-mediated induction of autophagy via an Apg1 protein kinase complex.

Kim J, et al. (2001 Apr 16). Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole.

Hutchins MU, et al. (2001 Jun 8). Vacuolar localization of oligomeric alpha-mannosidase requires the cytoplasm to vacuole targeting and autophagy pathway components in Saccharomyces cerevisiae.

Shintani T, et al. (2002 Dec). Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway.

Kim J, et al. (2002 Jan 4). Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation.

Klionsky DJ, et al. (2003 Oct). A unified nomenclature for yeast autophagy-related genes.

Shintani T, et al. (2004 Jul 16). Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway.

Yorimitsu T, et al. (2005 Apr). Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway.

He C, et al. (2006 Dec 18). Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast.

Yorimitsu T, et al. (2006 Oct 6). Endoplasmic reticulum stress triggers autophagy.

Suzuki K, et al. (2007 Feb). Hierarchy of Atg proteins in pre-autophagosomal structure organization.

Cao Y, et al. (2007 Jan-Feb). Atg26 is not involved in autophagy-related pathways in Saccharomyces cerevisiae.

Chang CY, et al. (2007 Mar). Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy.

Ma J, et al. (2008 Aug). Localization of autophagy-related proteins in yeast using a versatile plasmid-based resource of fluorescent protein fusions.

Cao Y, et al. (2008 Aug 25). In vivo reconstitution of autophagy in Saccharomyces cerevisiae.

Cheong H, et al. (2008 Feb). The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae.

Geng J, et al. (2008 Jul 14). Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy.

Kawamata T, et al. (2008 May). Organization of the pre-autophagosomal structure responsible for autophagosome formation.

Kanki T, et al. (2008 Nov 21). Mitophagy in yeast occurs through a selective mechanism.

Krick R, et al. (2008 Oct). Piecemeal microautophagy of the nucleus requires the core macroautophagy genes.

Kageyama T, et al. (2009 Jan 16). Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae.

Kanki T, et al. (2009 Jul). Atg32 is a mitochondrial protein that confers selectivity during mitophagy.

Okamoto K, et al. (2009 Jul). Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.

Lin YY, et al. (2009 Mar 20). Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis.

Sekito T, et al. (2009 May). Atg17 recruits Atg9 to organize the pre-autophagosomal structure.

Roetzer A, et al. (2010 Feb). Autophagy supports Candida glabrata survival during phagocytosis.

Ecker N, et al. (2010 Oct). Induction of autophagic flux by amino acid deprivation is distinct from nitrogen starvation-induced macroautophagy.

Mari M, et al. (2010 Sep 20). An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis.

Suzuki K, et al. (2010 Sep 24). Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p.

Mendl N, et al. (2011 Apr 15). Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2.

Yuga M, et al. (2011 Apr 15). Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae.

Aoki Y, et al. (2011 Sep). Phosphorylation of Serine 114 on Atg32 mediates mitophagy.

Mijaljica D, et al. (2012). A late form of nucleophagy in Saccharomyces cerevisiae.

Kurihara Y, et al. (2012 Jan 27). Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast.

Kondo-Okamoto N, et al. (2012 Mar 23). Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.

Lipatova Z, et al. (2012 May 1). Regulation of selective autophagy onset by a Ypt/Rab GTPase module.

Farré JC, et al. (2013 May). Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11.

Aris JP, et al. (2013 Oct). Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 10 genes with posterior transmembrane prediction > 50%