FOG11950
EOG8NS1T9

sce:SYF1

Genes: 31

SGD Description
Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans


PomBase Description
complexed with Cdc5 protein Cwf3


AspGD Description
Ortholog(s) have Prp19 complex, cytosol, mitotic spindle pole body, spliceosomal complex localization


References

McDonald WH, et al. (1999 Aug). Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing.

Ben-Yehuda S, et al. (2000 Dec). Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae.

Russell CS, et al. (2000 Nov). Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae.

Ohi MD, et al. (2002 Apr). Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.

Chen CH, et al. (2002 Feb 15). Functional and physical interactions between components of the Prp19p-associated complex.

Ohi MD, et al. (2002 Jun). Characterization of interactions among the Cef1p-Prp19p-associated splicing complex.

Taricani L, et al. (2002 Mar 22). The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.

Carnahan RH, et al. (2005 Mar). Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Grenier St-Sauveur V, et al. (2013 Dec). Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Livesay SB, et al. (2013 Nov). Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Bayne EH, et al. (2014). A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Kallgren SP, et al. (2014). The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen W, et al. (2014 Mar). Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.

Wang J, et al. (2014 Oct). Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%