FOG11949
EOG8NS1TD

sce:KEX1

Genes: 34

SGD Description
Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins


PomBase Description
serine carboxypeptidase (predicted)


AspGD Description
Ortholog(s) have serine-type carboxypeptidase activity, role in apoptotic process, hyphal growth, positive regulation of conidium formation and fungal-type vacuole, trans-Golgi network localization


References

Wickner RB, et al. (1974 Mar). Chromosomal and nonchromosomal mutations affecting the "killer character" of Saccharomyces cerevisiae.

Wickner RB, et al. (1976 Mar 25). Two chromosomal genes required for killing expression in killer strains of Saccharomyces cerevisiae.

Dmochowska A, et al. (1987 Aug 14). Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing.

Zhu H, et al. (1987 Aug 5). Determination of the carboxyl termini of the alpha and beta subunits of yeast K1 killer toxin. Requirement of a carboxypeptidase B-like activity for maturation.

Wagner JC, et al. (1987 Sep 14). Hormone (pheromone) processing enzymes in yeast. The carboxy-terminal processing enzyme of the mating pheromone alpha-factor, carboxypeptidase ysc alpha, is absent in alpha-factor maturation-defective kex1 mutant cells.

Cooper A, et al. (1989 Jun). Characterization of the yeast KEX1 gene product: a carboxypeptidase involved in processing secreted precursor proteins.

Cooper A, et al. (1992 Dec). Yeast Kex1p is a Golgi-associated membrane protein: deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane.

Latchinian-Sadek L, et al. (1993 Jan 5). Expression, purification, and characterization of the yeast KEX1 gene product, a polypeptide precursor processing carboxypeptidase.

Shilton BH, et al. (1996 Feb). Crystallization of a soluble form of the Kex1p serine carboxypeptidase from Saccharomyces cerevisiae.

Shilton BH, et al. (1997 Jul 22). Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae,.

Eisfeld K, et al. (2000 Aug). Endocytotic uptake and retrograde transport of a virally encoded killer toxin in yeast.

Riffer F, et al. (2002 May). Mutational analysis of K28 preprotoxin processing in the yeast Saccharomyces cerevisiae.

Dyer PS, et al. (2003 Sep). Genomics reveals sexual secrets of Aspergillus.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Heiman MG, et al. (2007 Jan 15). The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating.

Hauptmann P, et al. (2008 Jul 4). Kex1 protease is involved in yeast cell death induced by defective N-glycosylation, acetic acid, and chronological aging.

Ravin NV, et al. (2013 Nov 27). Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha DL1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%