FOG11276
EOG8QJQ72

sce:SKP1

Genes: 31

SGD Description
Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress


PomBase Description
SCF ubiquitin ligase complex subunit Skp1


References

Natorff R, et al. (1993 Apr). At least four regulatory genes control sulphur metabolite repression in Aspergillus nidulans.

Paszewski A, et al. (1994). Sulphur metabolism.

Stemmann O, et al. (1996 Jul 15). The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution.

Bai C, et al. (1996 Jul 26). SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

Connelly C, et al. (1996 Jul 26). Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Feldman RM, et al. (1997 Oct 17). A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.

Skowyra D, et al. (1997 Oct 17). F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.

Patton EE, et al. (1998 Mar 1). Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.

Rouillon A, et al. (2000 Jan 17). Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.

Piotrowska M, et al. (2000 Oct). sconC, a gene involved in the regulation of sulphur metabolism in Aspergillus nidulans, belongs to the SKP1 gene family.

Seol JH, et al. (2001 Apr). Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.

Galan JM, et al. (2001 May). Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast.

Orlicky S, et al. (2003 Jan 24). Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.

Brunson LE, et al. (2004 Feb 20). The amino-terminal portion of the F-box protein Met30p mediates its nuclear import and assimilation into an SCF complex.

Rodrigo-Brenni MC, et al. (2004 Jul). Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function.

Pócsi I, et al. (2005 Dec 20). Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology.

Escusa S, et al. (2007 Jul 13). Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1p.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Liu Y, et al. (2011 May). Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

von Zeska Kress MR, et al. (2012 Mar). The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development.

Sieńko M, et al. (2014 Apr). Regulatory mutations affecting sulfur metabolism induce environmental stress response in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%