FOG11253
EOG8QNKCX

sce:SNF4

Genes: 32

SGD Description
Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress


PomBase Description
AMP-activated protein kinase gamma subunit cbs2


AspGD Description
Ortholog(s) have AMP binding, AMP-activated protein kinase activity, ATP binding, protein serine/threonine kinase activator activity


References

Entian KD, et al. (1982 Sep). New genes involved in carbon catabolite repression and derepression in the yeast Saccharomyces cerevisiae.

Neigeborn L, et al. (1984 Dec). Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae.

Sarokin L, et al. (1985 Oct). Upstream region of the SUC2 gene confers regulated expression to a heterologous gene in Saccharomyces cerevisiae.

Schüller HJ, et al. (1988 Jul 30). Molecular characterization of yeast regulatory gene CAT3 necessary for glucose derepression and nuclear localization of its product.

Bisson LF, et al. (1988 Oct). High-affinity glucose transport in Saccharomyces cerevisiae is under general glucose repression control.

Celenza JL, et al. (1989 Nov). Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase.

Celenza JL, et al. (1989 Nov). Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein.

Argüelles JC, et al. (1990). Absence of glucose-induced cAMP signaling in the Saccharomyces cerevisiae mutants cat1 and cat3 which are deficient in derepression of glucose-repressible proteins.

Swanson MS, et al. (1990 Sep). SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.

Estruch F, et al. (1992 Nov). N-terminal mutations modulate yeast SNF1 protein kinase function.

Fernandez E, et al. (1993 Nov 1). Transcriptional regulation of the isocitrate lyase encoding gene in Saccharomyces cerevisiae.

Mitchelhill KI, et al. (1994 Jan 28). Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

Blázquez MA, et al. (1995 Dec 20). Mode of action of the qcr9 and cat3 mutations in restoring the ability of Saccharomyces cerevisiae tps1 mutants to grow on glucose.

Jiang R, et al. (1996 Dec 15). Glucose regulates protein interactions within the yeast SNF1 protein kinase complex.

Jiang R, et al. (1997 Apr). The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex.

Aon MA, et al. (1998 Jul 20). Catabolite repression mutants of Saccharomyces cerevisiae show altered fermentative metabolism as well as cell cycle behavior in glucose-limited chemostat cultures.

Ludin K, et al. (1998 May 26). Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae.

Aon MA, et al. (1999 Jan). Quantitation of the effects of disruption of catabolite (de)repression genes on the cell cycle behavior of Saccharomyces cerevisiae.

Shirra MK, et al. (1999 May). Evidence for the involvement of the Glc7-Reg1 phosphatase and the Snf1-Snf4 kinase in the regulation of INO1 transcription in Saccharomyces cerevisiae.

McCartney RR, et al. (2001 Sep 28). Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit.

Nath N, et al. (2002 Dec 27). Purification and characterization of Snf1 kinase complexes containing a defined Beta subunit composition.

Haurie V, et al. (2003 Nov 14). The Snf1 protein kinase controls the induction of genes of the iron uptake pathway at the diauxic shift in Saccharomyces cerevisiae.

Elbing K, et al. (2006 Sep 8). Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity.

Rudolph MJ, et al. (2007 Jan). Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding.

Sarma NJ, et al. (2007 Mar). Glucose-responsive regulators of gene expression in Saccharomyces cerevisiae function at the nuclear periphery via a reverse recruitment mechanism.

Townley R, et al. (2007 Mar 23). Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase.

Amodeo GA, et al. (2007 Sep 27). Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1.

Momcilovic M, et al. (2008 Jul 11). Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase.

Hanyu Y, et al. (2009 May). Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Mayer FV, et al. (2011 Nov 2). ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.

Matsuzawa T, et al. (2012 Feb). Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.

Valbuena N, et al. (2012 Jun 1). AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Davie E, et al. (2015 Feb 16). Nitrogen regulates AMPK to control TORC1 signaling.

Saitoh S, et al. (2015 Jan 15). Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%