FOG11221
EOG8QRFMC

sce:RFT1

Genes: 32

SGD Description
Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; essential gene


PomBase Description
Man5GlcNac2-PP-Dol translocation protein Rft1 (predicted)


AspGD Description
Putative flippase; expression enhanced by maltose; expression induced by tunicamycin and DTT


References

Hahn S, et al. (1988 Feb). The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts.

Mulder W, et al. (1994 Oct 17). Sequence of the HAP3 transcription factor of Kluyveromyces lactis predicts the presence of a novel 4-cysteine zinc-finger motif.

Koerte A, et al. (1995 Sep 22). Suppression of the yeast mutation rft1-1 by human p53.

Helenius J, et al. (2002 Jan 24). Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%