FOG11217
EOG8QRFN4

sce:BXI1

Genes: 28

SGD Description
Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p


PomBase Description
BAX inhibitor family protein Bxi1


AspGD Description
Ortholog(s) have Golgi apparatus, fungal-type vacuole membrane localization


References

Lamb HK, et al. (1990 Aug). Spatial and biological characterisation of the complete quinic acid utilisation gene cluster in Aspergillus nidulans.

Arst HN Jr, et al. (2003 Aug 1). Re: Watts et al. Proteins 2002;48:161-168.

Mogensen J, et al. (2006 Aug). Transcription analysis using high-density micro-arrays of Aspergillus nidulans wild-type and creA mutant during growth on glucose or ethanol.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Cebulski J, et al. (2011). Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae.

Büttner S, et al. (2011 Jun 14). A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis.

Castillo K, et al. (2011 Sep 16). BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 28 genes with posterior transmembrane prediction > 50%