FOG11193
EOG8QV9ST

sce:SCC2

Genes: 33

SGD Description
Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin; relocalizes to the cytosol in response to hypoxia


PomBase Description
adherin, cohesin loading factor Mis4


AspGD Description
Ortholog(s) have role in attachment of mitotic spindle microtubules to kinetochore, cohesin localization to chromatin, mitotic sister chromatid cohesion and negative regulation of G0 to G1 transition, more


References

Michaelis C, et al. (1997 Oct 3). Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.

Tóth A, et al. (1999 Feb 1). Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.

Ciosk R, et al. (2000 Feb). Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins.

Arumugam P, et al. (2003 Nov 11). ATP hydrolysis is required for cohesin's association with chromosomes.

Lopez-Serra L, et al. (2014 Oct). The Scc2-Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions.

Hinshaw SM, et al. (2015 Jun 3). Structural evidence for Scc4-dependent localization of cohesin loading.

Woodman J, et al. (2015 Nov 1). Phosphorylation of the Scc2 cohesin deposition complex subunit regulates chromosome condensation through cohesin integrity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%