FOG11192
EOG8QV9T0

sce:MCD4

Genes: 32

SGD Description
Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol


PomBase Description
pig-N (predicted)


AspGD Description
Ortholog(s) have mannose-ethanolamine phosphotransferase activity and role in ATP transport, GPI anchor biosynthetic process, conidium formation, fungal-type cell wall organization or biogenesis, regulation of growth rate


References

Gaynor EC, et al. (1999 Mar). MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.

Packeiser AN, et al. (1999 Oct). A novel vacuolar protein encoded by SSU21 / MCD4 is involved in cell wall integrity in yeast.

Storey MK, et al. (2001 Jun 29). A genetic screen for ethanolamine auxotrophs in Saccharomyces cerevisiae identifies a novel mutation in Mcd4p, a protein implicated in glycosylphosphatidylinositol anchor synthesis.

Kalebina TS, et al. (2002 Apr 23). Correct GPI-anchor synthesis is required for the incorporation of endoglucanase/glucanosyltransferase Bgl2p into the Saccharomyces cerevisiae cell wall.

Zhong X, et al. (2003 Aug 29). ATP uptake in the Golgi and extracellular release require Mcd4 protein and the vacuolar H+-ATPase.

Maneesri J, et al. (2005 Apr). Deletion of MCD 4 involved in glycosylphosphatidylinositol (GPI) anchor synthesis leads to an increase in beta-1,6-glucan level and a decrease in GPI-anchored protein and mannan levels in the cell wall of Saccharomyces cerevisiae.

Zhu Y, et al. (2006 Jul 21). Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%