FOG11182
EOG8QV9VD

sce:SPT14

Genes: 33

SGD Description
UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins


PomBase Description
pig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3 (predicted)


AspGD Description
Ortholog(s) have acetylglucosaminyltransferase activity and role in GPI anchor biosynthetic process, conidium formation, establishment or maintenance of cell polarity, fungal-type cell wall biogenesis, regulation of growth rate


References

Fassler JS, et al. (1991 Nov). The Saccharomyces cerevisiae SPT14 gene is essential for normal expression of the yeast transposon, Ty, as well as for expression of the HIS4 gene and several genes in the mating pathway.

Schönbächler M, et al. (1995 Apr 18). The yeast spt14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis.

Leidich SD, et al. (1995 Jun 2). Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene.

Davis CA, et al. (2000 Apr 15). Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast.

Kostova Z, et al. (2000 Sep 15). Photoaffinity labelling with P3-(4-azidoanilido)uridine 5'-triphosphate identifies gpi3p as the UDP-GlcNAc-binding subunit of the enzyme that catalyses formation of GlcNAc-phosphatidylinositol, the first glycolipid intermediate in glycosylphosphatidylinositol synthesis.

Kostova Z, et al. (2003 Nov). Comparative importance in vivo of conserved glutamate residues in the EX7E motif retaining glycosyltransferase Gpi3p, the UDP-GlcNAc-binding subunit of the first enzyme in glycosylphosphatidylinositol assembly.

Sobering AK, et al. (2004 May 28). Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%