FOG05338
EOG83R23V

sce:RAD9

Genes: 22

SGD Description
DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain (CAD) is phosphorylated at multiple sites by Cdc28p/Clb2p


PomBase Description
DNA repair protein Rad9 homolog Crb2


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN12204, A. fumigatus Af293 : Afu5g04020, A. oryzae RIB40 : AO090102000605, Neosartorya fischeri NRRL 181 : NFIA_038090 and Aspergillus wentii : Aspwe1_0043117


References

Schiestl RH, et al. (1989 May). Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage.

Weinert TA, et al. (1990 Dec). Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage.

Vialard JE, et al. (1998 Oct 1). The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%