FOG05295
EOG851C6X

sce:SRC1;HEH2

Genes: 32

SGD Description
Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SEC1 has a paralog, HEH2, that arose from the whole genome duplication|Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog, SRC1, that arose from the whole genome duplication


PomBase Description
LEM domain protein Heh1/Lem2|LEM domain protein Man1, Sad1 interacting factor


AspGD Description
Ortholog(s) have role in attachment of telomere to nuclear envelope, maintenance of rDNA, mitotic sister chromatid segregation, nuclear envelope organization


References

Rodríguez-Navarro S, et al. (2002 Jan 15). SRC1: an intron-containing yeast gene involved in sister chromatid segregation.

King MC, et al. (2006 Aug 31). Karyopherin-mediated import of integral inner nuclear membrane proteins.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%