FOG05291
EOG8573QT

sce:SPA2

Genes: 31

SGD Description
Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication


PomBase Description
cell polarity protein Spa2


AspGD Description
Polarisome component; localises to hyphal tips and is important for polarized growth


References

Gehrung S, et al. (1990 Oct). The SPA2 gene of Saccharomyces cerevisiae is important for pheromone-induced morphogenesis and efficient mating.

Mino A, et al. (1998 Oct 29). Shs1p: a novel member of septin that interacts with spa2p, involved in polarized growth in saccharomyces cerevisiae.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG05292
EOG8573QT

sce:SPH1

Genes: 2

SGD Description
Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; SPH1 has a paralog, SPA2, that arose from the whole genome duplication


References

Arkowitz RA, et al. (1997 Jul 14). A small conserved domain in the yeast Spa2p is necessary and sufficient for its polarized localization.

Roemer T, et al. (1998 Feb). The Spa2-related protein, Sph1p, is important for polarized growth in yeast.

Dittmar GA, et al. (2002 Mar 29). Role of a ubiquitin-like modification in polarized morphogenesis.

Sundin BA, et al. (2004 Jul 15). Localization of proteins that are coordinately expressed with Cln2 during the cell cycle.

Zhang Z, et al. (2005 Aug). Identification and characterization of upstream open reading frames (uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%