FOG05290
EOG8573TH

sce:VMA21

Genes: 19

SGD Description
Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human XMEA (X-linked Myopathy with Excessive Autophagy); functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)


AspGD Description
Ortholog(s) have role in vacuolar proton-transporting V-type ATPase complex assembly and endoplasmic reticulum membrane localization


References

Ho MN, et al. (1993 Jan 5). Isolation of vacuolar membrane H(+)-ATPase-deficient yeast mutants; the VMA5 and VMA4 genes are essential for assembly and activity of the vacuolar H(+)-ATPase.

Hill KJ, et al. (1994 Sep). Vma21p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex.

Malkus P, et al. (2004 Nov). Role of Vma21p in assembly and transport of the yeast vacuolar ATPase.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Compton MA, et al. (2006 Jun 2). Vma9p (subunit e) is an integral membrane V0 subunit of the yeast V-ATPase.

Welsh LM, et al. (2006 Nov 15). Genetic and molecular interactions of the Erv41p-Erv46p complex involved in transport between the endoplasmic reticulum and Golgi complex.

Davis-Kaplan SR, et al. (2006 Oct 20). PKR1 encodes an assembly factor for the yeast V-type ATPase.

Ryan M, et al. (2008 Dec). Voa1p functions in V-ATPase assembly in the yeast endoplasmic reticulum.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 18 genes with posterior transmembrane prediction > 50%