FOG05265
EOG85MKMP
sce:MBP1
Genes: 34
EOG85MKMP
sce:MBP1
Genes: 34
SGD Description
Transcription factor; involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
PomBase Description
MBF transcription factor complex subunit Res1|MBF transcription factor complex subunit Res2
AspGD Description
Ortholog(s) have RNA polymerase II core promoter proximal region sequence-specific DNA binding, sequence-specific DNA binding and transcriptional activator activity, more
References
Koch C, et al. (1993 Sep 17). A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase.
Benton BK, et al. (1996 Jan). Over-expression of S. cerevisiae G1 cyclins restores the viability of alg1 N-glycosylation mutants.
Xu RM, et al. (1997 Mar 15). Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell-cycle control of DNA synthesis.
Taylor IA, et al. (1997 Sep 12). The X-ray structure of the DNA-binding domain from the Saccharomyces cerevisiae cell-cycle transcription factor Mbp1 at 2.1 A resolution.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.
Ashe M, et al. (2008 Mar 7). The SBF- and MBF-associated protein Msa1 is required for proper timing of G1-specific transcription in Saccharomyces cerevisiae.
Lee JY, et al. (2013 Dec). A putative APSES transcription factor is necessary for normal growth and development of Aspergillus nidulans.
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG05266
EOG85MKMP
EOG8C2FRK
sce:SWI6
Genes: 33
EOG85MKMP
EOG8C2FRK
sce:SWI6
Genes: 33
SGD Description
Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators
PomBase Description
MBF transcription factor complex subunit Cdc10
AspGD Description
Has domain(s) with predicted DNA binding, transcription factor activity, sequence-specific DNA binding activity and role in regulation of transcription, DNA-templated
References
Nurse P, et al. (1976 Jul 23). Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.
Nasmyth K, et al. (1981). Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe.
Beach D, et al. (1985). ran1+ controls the transition from mitotic division to meiosis in fission yeast.
Aves SJ, et al. (1985 Feb). Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene.
Young PG, et al. (1987 Oct). Schizosaccharomyces pombe mutants affected in their division response to starvation.
Breeden L, et al. (1987 Oct 15-21). Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila.
Alfa CE, et al. (1989). Fission yeast cyclin: subcellular localisation and cell cycle regulation.
Simanis V, et al. (1989 Jan). Characterization of the fission yeast cdc10+ protein that is required for commitment to the cell cycle.
Enoch T, et al. (1990 Feb 23). Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.
Grallert B, et al. (1991 Aug). Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.
Tanaka K, et al. (1992 Dec). A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products.
Dirick L, et al. (1992 Jun 11). A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast.
Marks J, et al. (1992 Mar). Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe.
Reymond A, et al. (1992 Sep). Mutations in the cdc10 start gene of Schizosaccharomyces pombe implicate the region of homology between cdc10 and SWI6 as important for p85cdc10 function.
Caligiuri M, et al. (1993 Feb 26). Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation.
Kelly TJ, et al. (1993 Jul 30). The fission yeast cdc18+ gene product couples S phase to START and mitosis.
Saka Y, et al. (1993 Jul 30). Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+.
Koch C, et al. (1993 Sep 17). A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase.
Miyamoto M, et al. (1994 Apr 15). res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast.
Obara-Ishihara T, et al. (1994 Apr 15). A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.
Sugiyama A, et al. (1994 Apr 15). A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade.
Zhu Y, et al. (1994 Apr 15). pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for meiosis in the fission yeast Schizosaccharomyces pombe.
Hofmann JF, et al. (1994 Jan 15). cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.
Ohi R, et al. (1994 Jan 15). The Schizosaccharomyces pombe cdc5+ gene encodes an essential protein with homology to c-Myb.
Snell V, et al. (1994 May 1). Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth.
Saka Y, et al. (1994 Nov 15). Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.
Hayles J, et al. (1994 Sep 9). Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex.
Hayles J, et al. (1995 Jun 15). A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.
Ayté J, et al. (1995 May). The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase.
Nishitani H, et al. (1995 Nov 3). p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast.
Labib K, et al. (1995 Oct). Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast.
Nakashima N, et al. (1995 Oct 2). Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10.
Mondesert O, et al. (1996 Apr). Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe.
Okishio N, et al. (1996 Feb). Fission yeast Nda1 and Nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins.
Fisher DL, et al. (1996 Feb 15). A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.
Funabiki H, et al. (1996 May 30). Cut2 proteolysis required for sister-chromatid seperation in fission yeast.
Yamano H, et al. (1996 Oct 1). The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.
Toda T, et al. (1996 Sep). The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.
Woollard A, et al. (1996 Sep 2). A novel S phase inhibitor in fission yeast.
Stern B, et al. (1997 Feb 3). Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.
Shayeghi M, et al. (1997 Mar 15). Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.
Iino Y, et al. (1997 Mar 18). The Schizosaccharomyces pombe cdc6 gene encodes the catalytic subunit of DNA polymerase delta.
Zhu Y, et al. (1997 Mar 3). Functional characterization of the fission yeast Start-specific transcription factor Res2.
Carlson CR, et al. (1997 Nov). Measurement of nuclear DNA content in fission yeast by flow cytometry.
Funabiki H, et al. (1997 Oct 1). Fission yeast Cut2 required for anaphase has two destruction boxes.
Krien MJ, et al. (1998 Apr). A NIMA homologue promotes chromatin condensation in fission yeast.
Bhaumik D, et al. (1998 Aug). Mutational effect of fission yeast polalpha on cell cycle events.
Hirata D, et al. (1998 Jan). Genes that cause aberrant cell morphology by overexpression in fission yeast: a role of a small GTP-binding protein Rho2 in cell morphogenesis.
Sawin KE, et al. (1998 Jul 27). Regulation of cell polarity by microtubules in fission yeast.
Sánchez-Díaz A, et al. (1998 Mar). The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.
Kitamura K, et al. (1998 May). Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase.
Bähler J, et al. (1998 May 1). Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.
Ho Y, et al. (1999 Aug). Regulation of transcription at the Saccharomyces cerevisiae start transition by Stb1, a Swi6-binding protein.
Foord R, et al. (1999 Feb). X-ray structural analysis of the yeast cell cycle regulator Swi6 reveals variations of the ankyrin fold and has implications for Swi6 function.
Grenon M, et al. (1999 Jan). The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.
Snaith HA, et al. (1999 Jul). Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.
Whitehall S, et al. (1999 Nov). Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription.
Sawin KE, et al. (1999 Nov 18). Mis-specification of cortical identity in a fission yeast PAK mutant.
Ogawa Y, et al. (1999 Oct). Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins.
Forsburg SL, et al. (2000 Jul). Mitotic replication initiation proteins are not required for pre-meiotic S phase.
Tanaka K, et al. (2000 May). Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.
Tatebe H, et al. (2000 Nov 2). Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.
Tournier S, et al. (2000 Oct). A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.
Ng SS, et al. (2001 Aug 17). mik1(+) G1-S transcription regulates mitotic entry in fission yeast.
Ayté J, et al. (2001 Dec). Feedback regulation of the MBF transcription factor by cyclin Cig2.
West RR, et al. (2001 Dec). Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast.
Decottignies A, et al. (2001 Jul). In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.
Huang HK, et al. (2001 Oct). Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe.
Anderson M, et al. (2002 Nov 1). Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle.
Synnes M, et al. (2002 Sep 15). A novel chk1-dependent G1/M checkpoint in fission yeast.
Feng W, et al. (2003 Aug). Schizosacchromyces pombe Dpb2 binds to origin DNA early in S phase and is required for chromosomal DNA replication.
Yoshida SH, et al. (2003 Jul). The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication.
Queralt E, et al. (2003 May). Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling.
Gregan J, et al. (2003 Sep). Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding.
Maqbool Z, et al. (2003 Sep). MCB-mediated regulation of cell cycle-specific cdc22+ transcription in fission yeast.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Bulmer R, et al. (2004 Aug). The forkhead transcription factor Fkh2 regulates the cell division cycle of Schizosaccharomyces pombe.
Cunliffe L, et al. (2004 Feb). DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.
Geymonat M, et al. (2004 Mar). Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6.
Kumar S, et al. (2004 Oct 15). On the slowing of S phase in response to DNA damage in fission yeast.
Castagnetti S, et al. (2005 May 1). End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe.
Kanai M, et al. (2005 Sep 7). Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.
de Bruin RA, et al. (2006 Aug). Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
Locovei AM, et al. (2006 Nov 17). The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.
Nadeem FK, et al. (2006 Oct). Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production.
Choi E, et al. (2006 Oct 31). Function of rax2p in the polarized growth of fission yeast.
Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Neumann FR, et al. (2007 Nov 19). Nuclear size control in fission yeast.
Limbo O, et al. (2007 Oct 12). Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.
de Bruin RA, et al. (2008 Aug 12). DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1.
Ashe M, et al. (2008 Mar 7). The SBF- and MBF-associated protein Msa1 is required for proper timing of G1-specific transcription in Saccharomyces cerevisiae.
Dutta C, et al. (2008 Oct). The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription.
Aligianni S, et al. (2009 Aug). The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Dutta C, et al. (2009 Sep 11). The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.
Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.
Cadou A, et al. (2010 Sep). Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.
Purtill FS, et al. (2011 Feb 15). A homeodomain transcription factor regulates the DNA replication checkpoint in yeast.
Gómez-Escoda B, et al. (2011 Jan). Yox1 links MBF-dependent transcription to completion of DNA synthesis.
Rodríguez-Sánchez L, et al. (2011 Jan 1). The fission yeast rDNA-binding protein Reb1 regulates G1 phase under nutritional stress.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Vachon L, et al. (2013 Aug). Functional characterization of fission yeast transcription factors by overexpression analysis.
Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Ivanova T, et al. (2013 Nov). The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Bendezú FO, et al. (2015 Apr). Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.
Cohen A, et al. (2016 Apr 22). Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.
Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG05267
EOG85MKMP
EOG870RZX
sce:SWI4
Genes: 22
EOG85MKMP
EOG870RZX
sce:SWI4
Genes: 22
SGD Description
DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; Slt2p-independent regulator of cold growth; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p
References
Andrews BJ, et al. (1989 Dec 14). The yeast SWI4 protein contains a motif present in developmental regulators and is part of a complex involved in cell-cycle-dependent transcription.
Daniel J, et al. (1993 Aug). Potentially rapid walking in cellular regulatory networks using the gene-gene interference method in yeast.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Ashe M, et al. (2008 Mar 7). The SBF- and MBF-associated protein Msa1 is required for proper timing of G1-specific transcription in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG05268
EOG870RZX
sce:absent
Genes: 1
EOG870RZX
sce:absent
Genes: 1
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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