FOG05262
EOG85MKN0

sce:RIM11

Genes: 33

SGD Description
Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication


PomBase Description
serine/threonine protein kinase Gsk3


AspGD Description
Ortholog(s) have protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity


References

Bianchi MW, et al. (1993 Nov 30). A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product.

Bowdish KS, et al. (1994 Dec). Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1.

Puziss JW, et al. (1994 Jan). MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3.

Zhan XL, et al. (2000 Feb). Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Fasolo J, et al. (2011 Apr 1). Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Hernández-Ortiz P, et al. (2013 Aug). Phospho-regulation and nucleocytoplasmic trafficking of CrzA in response to calcium and alkaline-pH stress in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG05263
EOG85MKN0

sce:MCK1

Genes: 23

SGD Description
Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication


References

Dailey D, et al. (1990 Dec). Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity.

Neigeborn L, et al. (1991 Apr). The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression.

Shero JH, et al. (1991 Apr). A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1).

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG05264
EOG85MKN0

sce:YGK3;MRK1

Genes: 3

SGD Description
Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication|Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication


PomBase Description
serine/threonine protein kinase Gsk31 (predicted)


References

Hardy TA, et al. (1995 Mar 17). Novel Saccharomyces cerevisiae gene, MRK1, encoding a putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy.

Andoh T, et al. (2000 Sep). Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5.

Hirata Y, et al. (2003 Jan). Yeast glycogen synthase kinase-3 activates Msn2p-dependent transcription of stress responsive genes.

Griffioen G, et al. (2003 Jun 27). Feedback inhibition on cell wall integrity signaling by Zds1 involves Gsk3 phosphorylation of a cAMP-dependent protein kinase regulatory subunit.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%