FOG05160
EOG88GTKM

sce:HMLALPHA2;HMRA2;MATALPHA2

Genes: 8

SGD Description
Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression|Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system|Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette


References

Nasmyth KA, et al. (1981). Physical analysis of mating-type loci in Saccharomyces cerevisiae.

Nasmyth KA, et al. (1981 Jan 22). A position effect in the control of transcription at yeast mating type loci.

Astell CR, et al. (1981 Nov). The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae.

Tatchell K, et al. (1981 Nov). In vitro mutation analysis of the mating-type locus in yeast.

Shepherd JC, et al. (1984 Jul 5-11). Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins.

Johnson AD, et al. (1985 Aug). A repressor (MAT alpha 2 Product) and its operator control expression of a set of cell type specific genes in yeast.

Hall MN, et al. (1987 Aug 28). Homeo domain of the yeast repressor alpha 2 is a sequence-specific DNA-binding domain but is not sufficient for repression.

Sauer RT, et al. (1988 Jul). Flexibility of the yeast alpha 2 repressor enables it to occupy the ends of its operator, leaving the center free.

Strathern J, et al. (1988 Sep). a/Alpha-specific repression by MAT alpha 2.

Phillips CL, et al. (1991 May). Secondary structure of the homeo domain of yeast alpha 2 repressor determined by NMR spectroscopy.

Wolberger C, et al. (1991 Nov 1). Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.

Sor F, et al. (1992 Mar). Sequence of the HMR region on chromosome III of Saccharomyces cerevisiae.

Komachi K, et al. (1994 Dec 1). The WD repeats of Tup1 interact with the homeo domain protein alpha 2.

Smith RL, et al. (1995 Dec 1). The tetratricopeptide repeats of Ssn6 interact with the homeo domain of alpha 2.

Johnson AD, et al. (1995 Oct). Molecular mechanisms of cell-type determination in budding yeast.

Li T, et al. (1995 Oct 13). Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA.

Mead J, et al. (1996 May). The yeast alpha2 and Mcm1 proteins interact through a region similar to a motif found in homeodomain proteins of higher eukaryotes.

Li T, et al. (1998 Dec 15). Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract.

Tan S, et al. (1998 Feb 12). Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex.

Smith RL, et al. (2000 Apr 11). A sequence resembling a peroxisomal targeting sequence directs the interaction between the tetratricopeptide repeats of Ssn6 and the homeodomain of alpha 2.

Aishima J, et al. (2002 Dec 1). A Hoogsteen base pair embedded in undistorted B-DNA.

Ke A, et al. (2002 Jul). Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2.

Wong S, et al. (2003). Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata.

Srikantha T, et al. (2003 Apr). Three mating type-like loci in Candida glabrata.

Brockert PJ, et al. (2003 Dec). Phenotypic switching and mating type switching of Candida glabrata at sites of colonization.

Hwang CS, et al. (2010 Feb 19). N-terminal acetylation of cellular proteins creates specific degradation signals.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG05161
EOG88GTKM

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG05162
EOG88GTKM

sce:HMRA1

Genes: 13

SGD Description
Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells


AspGD Description
Has domain(s) with predicted DNA binding, sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding activity and role in regulation of transcription, DNA-templated


References

Sor F, et al. (1992 Mar). Sequence of the HMR region on chromosome III of Saccharomyces cerevisiae.

Hull CM, et al. (1999 Aug 20). Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.

Aström SU, et al. (2000 Sep). Kluyveromyces lactis Sir2p regulates cation sensitivity and maintains a specialized chromatin structure at the cryptic alpha-locus.

Miller MG, et al. (2002 Aug 9). White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating.

Srikantha T, et al. (2003 Apr). Three mating type-like loci in Candida glabrata.

Tsong AE, et al. (2003 Nov 14). Evolution of a combinatorial transcriptional circuit: a case study in yeasts.

Butler G, et al. (2004 Feb 10). Evolution of the MAT locus and its Ho endonuclease in yeast species.

Pendrak ML, et al. (2004 Jun). Hemoglobin regulates expression of an activator of mating-type locus alpha genes in Candida albicans.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%