FOG05157
EOG88GTPD

sce:APS1

Genes: 33

SGD Description
Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex


PomBase Description
AP-1 adaptor complex sigma subunit Aps1


AspGD Description
Ortholog(s) have clathrin binding activity, role in Golgi to vacuole transport, endosomal transport and AP-1 adaptor complex, cytosol, endosome, nucleus localization


References

Nakai M, et al. (1993 Sep 23). Cloning of the YAP19 gene encoding a putative yeast homolog of AP19, the mammalian small chain of the clathrin-assembly proteins.

Phan HL, et al. (1994 Apr 1). The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex.

Yeung BG, et al. (1999 Nov). Adaptor complex-independent clathrin function in yeast.

Ma Y, et al. (2009 Aug). Deletion mutants of AP-1 adaptin subunits display distinct phenotypes in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG05158
EOG88GTPD

sce:APS3

Genes: 33

SGD Description
Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress


PomBase Description
AP-3 adaptor complex subunit Aps3 (predicted)


AspGD Description
Ortholog(s) have role in Golgi to vacuole transport, pathogenesis, protein targeting to vacuole and AP-3 adaptor complex, cytosol, nucleus localization


References

Panek HR, et al. (1997 Jul 16). Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex.

Cowles CR, et al. (1997 Oct 3). The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole.

Rehling P, et al. (1999 Oct). Formation of AP-3 transport intermediates requires Vps41 function.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Palmer GE, et al. (2010 Nov). Endosomal and AP-3-dependent vacuolar trafficking routes make additive contributions to Candida albicans hyphal growth and pathogenesis.

Ma Y, et al. (2011). Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Fang Y, et al. (2012 Apr). A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Zhang L, et al. (2013). Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Zhou H, et al. (2015 Oct). Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG05159
EOG88GTPD

sce:APS2

Genes: 32

SGD Description
Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex


PomBase Description
AP-2 adaptor complex subunit Aps2 (predicted)


AspGD Description
Ortholog(s) have AP-2 adaptor complex, cytosol, nucleus, prospore membrane localization


References

Kirchhausen T, et al. (1991 Jun 15). AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.

Yeung BG, et al. (1999 Nov). Adaptor complex-independent clathrin function in yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%