FOG04948
EOG8FN2ZS

sce:CDC48

Genes: 35

SGD Description
AAA ATPase; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing, in macroautophagy, PMN, RAD, ribophagy, homotypic ER membrane fusion, disassembly of Met30p from SCF complex; functional ortholog of human p97/VCP


PomBase Description
AAA family ATPase involved in ubiquitin-mediated protein degradation Cdc48


AspGD Description
Ortholog(s) have ATPase activity, protein phosphatase type 1 regulator activity, ubiquitin binding activity


References

Moir D, et al. (1982 Apr). Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies.

Fröhlich KU, et al. (1991 Aug). Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression.

Ye Y, et al. (2001 Dec 6). The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.

Rape M, et al. (2001 Nov 30). Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone.

Hitchcock AL, et al. (2001 Oct). The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation.

Jarosch E, et al. (2002 Feb). Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

Braun S, et al. (2002 Feb 15). Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Schuberth C, et al. (2004 Aug). Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation.

Rumpf S, et al. (2006 Jan 20). Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone.

Carvalho P, et al. (2006 Jul 28). Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Heo JM, et al. (2010 Nov 12). A stress-responsive system for mitochondrial protein degradation.

Tran JR, et al. (2011 Feb 18). A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Brandman O, et al. (2012 Nov 21). A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.

Defenouillère Q, et al. (2013 Mar 26). Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products.

Matsuda R, et al. (2014 Jan). Protein quality control systems associated with no-go and nonstop mRNA surveillance in yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04949
EOG8FN2ZS

sce:AFG2

Genes: 29

SGD Description
ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs


PomBase Description
ribosome biogenesis factor recycling AAA family ATPase (predicted)


References

Thorsness PE, et al. (1993 Nov). AFG2, an essential gene in yeast, encodes a new member of the Sec18p, Pas1p, Cdc48p, TBP-1 family of putative ATPases.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04950
EOG86Q58M
EOG8FN2ZS

sce:absent

Genes: 4

AspGD Description
Has domain(s) with predicted ATP binding, nucleoside-triphosphatase activity, nucleotide binding activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%