FOG04909
EOG8GMSFV

sce:IWR1

Genes: 24

SGD Description
RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress


References

Pagé N, et al. (2003 Mar). A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.

Krogan NJ, et al. (2006 Mar 30). Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.

Miura F, et al. (2006 Nov 21). A large-scale full-length cDNA analysis to explore the budding yeast transcriptome.

Juneau K, et al. (2007 Jan 30). High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing.

Peiró-Chova L, et al. (2009 Oct 16). The yeast RNA polymerase II-associated factor Iwr1p is involved in the basal and regulated transcription of specific genes.

Kanno T, et al. (2010 Jan). RNA-directed DNA methylation and plant development require an IWR1-type transcription factor.

Czeko E, et al. (2011 Apr 22). Iwr1 directs RNA polymerase II nuclear import.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%