FOG04825
EOG8J6Q5Z

sce:ROG3;ROD1

Genes: 37

SGD Description
Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY motif-mediated binding of the ubiquitin ligase Rsp5p is not required for adaptation; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; ROG3 has a paralog, ROD1, that arose from the whole genome duplication|Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication


PomBase Description
arrestin involved in ubiquitin-dependent endocytosis|arrestin/PY protein involved in ubiquitin-mediated endocytosis Rod1 (predicted)


AspGD Description
Ortholog(s) have ubiquitin protein ligase binding activity and role in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, positive regulation of receptor internalization


References

Kelly JM, et al. (1977 Nov 4). Increased and decreased sensitivity to carbon catabolite repression of enzymes of acetate metabolism in mutants of Aspergillus nidulans.

Wu AL, et al. (1996 Feb 9). ROD1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Andoh T, et al. (2002 Aug 14). PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Boase NA, et al. (2003 May). Molecular characterization and analysis of the acrB gene of Aspergillus nidulans: a gene identified by genetic interaction as a component of the regulatory network that includes the CreB deubiquitination enzyme.

Boase NA, et al. (2004 Aug). A role for creD, a carbon catabolite repression gene from Aspergillus nidulans, in ubiquitination.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Cuthbertson BJ, et al. (2008 Feb 1). Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe.

Roy P, et al. (2008 May). CreA-mediated repression in Aspergillus nidulans does not require transcriptional auto-regulation, regulated intracellular localisation or degradation of CreA.

Salazar M, et al. (2009 Dec). Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG04826
EOG8J6Q5Z

sce:ART5

Genes: 18

SGD Description
Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane


References

Gupta R, et al. (2007). Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast.

Lu JY, et al. (2008 Jan). Functional dissection of a HECT ubiquitin E3 ligase.

Lin CH, et al. (2008 Nov 14). Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04827
EOG8J6Q5Z

sce:absent

Genes: 2

AspGD Description
Ortholog of Aspergillus tubingensis : Asptu1_0136011, Aspergillus brasiliensis : Aspbr1_0198194, Aspergillus glaucus : Aspgl1_0034242 and Aspergillus kawachii : Aspka1_0178607|Protein of unknown function

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%