FOG04824
EOG8J9KDX

sce:CTI6

Genes: 31

SGD Description
Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain


PomBase Description
histone deacetylase complex subunit Cti6


AspGD Description
Ortholog(s) have methylated histone binding, transcription factor binding activity


References

Gavin AC, et al. (2002 Jan 10). Functional organization of the yeast proteome by systematic analysis of protein complexes.

Papamichos-Chronakis M, et al. (2002 Jun). Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1.

Puig S, et al. (2004 Jul 16). Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae.

Carrozza MJ, et al. (2005 Nov 10). Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex.

Keogh MC, et al. (2005 Nov 18). Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.

Crisp RJ, et al. (2006 Feb 8). Recruitment of Tup1p and Cti6p regulates heme-deficient expression of Aft1p target genes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%