FOG04549
EOG8RN8TZ

sce:RAS2;RAS1

Genes: 33

SGD Description
GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication|GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication


PomBase Description
GTPase Ras1


AspGD Description
Ras GTPase; expressed in germinating conidia


References

Dhar R, et al. (1984 Apr 25). Nucleotide sequence of two rasH related-genes isolated from the yeast Saccharomyces cerevisiae.

Kataoka T, et al. (1984 Jun). Genetic analysis of yeast RAS1 and RAS2 genes.

Powers S, et al. (1984 Mar). Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.

Fujiyama A, et al. (1986 Mar). Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae.

Deschenes RJ, et al. (1989 Jul 15). RAS2 protein of Saccharomyces cerevisiae is methyl-esterified at its carboxyl terminus.

Fujiyama A, et al. (1990 Feb 25). RAS2 protein of Saccharomyces cerevisiae undergoes removal of methionine at N terminus and removal of three amino acids at C terminus.

He B, et al. (1991 Dec 15). RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.

Hrycyna CA, et al. (1991 Jul). The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.

Fujiyama A, et al. (1991 Sep 25). S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation.

Som T, et al. (1994 Aug). Developmental decisions in Aspergillus nidulans are modulated by Ras activity.

Cannon JF, et al. (1994 Feb). Characterization of glycogen-deficient glc mutants of Saccharomyces cerevisiae.

Silberstein S, et al. (1995 Oct). The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms.

Boyartchuk VL, et al. (1997 Mar 21). Modulation of Ras and a-factor function by carboxyl-terminal proteolysis.

Mabuchi T, et al. (2000 Apr 7). ASC1/RAS2 suppresses the growth defect on glycerol caused by the atp1-2 mutation in the yeast Saccharomyces cerevisiae.

Hoffmann B, et al. (2000 Jul). c-Jun and RACK1 homologues regulate a control point for sexual development in Aspergillus nidulans.

Osherov N, et al. (2000 Jun). Conidial germination in Aspergillus nidulans requires RAS signaling and protein synthesis.

Pascon RC, et al. (2000 Jun). Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.

Sundaram S, et al. (2001 May). Isolation and characterization of a symbiosis-regulated ras from the ectomycorrhizal fungus Laccaria bicolor.

Leberer E, et al. (2001 Nov). Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans.

Fillinger S, et al. (2002 May). cAMP and ras signalling independently control spore germination in the filamentous fungus Aspergillus nidulans.

Shimizu K, et al. (2003 Nov). Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn(II)2Cys6 transcription factor in Aspergillus nidulans.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Bok JW, et al. (2004 Apr). LaeA, a regulator of secondary metabolism in Aspergillus spp.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Harispe L, et al. (2008 Jan). Ras GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans.

Fortwendel JR, et al. (2008 Sep). Aspergillus fumigatus RasA regulates asexual development and cell wall integrity.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Kalleda N, et al. (2013). Targeting fungal genes by diced siRNAs: a rapid tool to decipher gene function in Aspergillus nidulans.

Krijgsheld P, et al. (2013 Mar 15). Development in Aspergillus.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04550
EOG8RN8TZ

sce:RSR1

Genes: 30

SGD Description
GTP-binding protein of the Ras superfamily; required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases


AspGD Description
Ortholog(s) have GTPase activity, signal transducer activity


References

Bender A, et al. (1989 Dec). Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

Harispe L, et al. (2008 Jan). Ras GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04551
EOG8RN8TZ

sce:absent

Genes: 9

AspGD Description
Protein with a predicted role in hyphal growth; expressed in germinating conidia

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%