FOG04453
EOG8CFXR1

sce:PDC2

Genes: 17

SGD Description
Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions


Suggested Analysis
Absent in nfu yet required for PDC expression (Crabtree-effect)


References

Hohmann S, et al. (1993 Dec). Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae.

Kaiser B, et al. (1999 May). Identification of a gene encoding the pyruvate decarboxylase gene regulator CaPdc2p from Candida albicans.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04454
EOG8CFXR1
EOG8TQJRQ

sce:absent

Genes: 7

PomBase Description
CENP-B homolog|CENP-B homolog Cbh1|CENP-B homolog Cbh2


References

Murakami Y, et al. (1996 Jan 9). Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe.

Halverson D, et al. (1997 Feb 10). A centromere DNA-binding protein from fission yeast affects chromosome segregation and has homology to human CENP-B.

Baum M, et al. (2000 Apr). Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation.

Irelan JT, et al. (2001 Mar). Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B.

Nakagawa H, et al. (2002 Jul 15). Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications.

Taricani L, et al. (2002 Mar 22). The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.

Fedyanina OS, et al. (2006 Nov). Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D.

Locovei AM, et al. (2006 Nov 17). The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.

Aguilar-Arnal L, et al. (2008 Apr 9). The fission yeast homologue of CENP-B, Abp1, regulates directionality of mating-type switching.

Cam HP, et al. (2008 Jan 24). Host genome surveillance for retrotransposons by transposon-derived proteins.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Zaratiegui M, et al. (2011 Jan 6). CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Lorenz DR, et al. (2012 Oct). CENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons.

Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Sánchez A, et al. (2015 Mar 19). Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Zhang X, et al. (2015 Oct 9). Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Murton HE, et al. (2016 Aug). Restriction of Retrotransposon Mobilization in Schizosaccharomyces pombe by Transcriptional Silencing and Higher-Order Chromatin Organization.

McDonald KR, et al. (2016 Sep). Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04455
EOG8TQJRQ

sce:absent

Genes: 4

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04456
EOG8CFXR1

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04457
EOG8TQJRQ

sce:absent

Genes: 4

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%