FOG04418
EOG8VT4C1

sce:RSP5

Genes: 35

SGD Description
E3 ubiquitin ligase of NEDD4 family; regulates many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, ribosome stability; mutant tolerates aneuploidy; autoubiquitinates; ubiquitinates Sec23p, Sna3p; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; human homolog implicated in Liddle syndrome


PomBase Description
HECT-type ubiquitin-protein ligase E3 Pub1|HECT-type ubiquitin-protein ligase E3 Pub3 (predicted)


AspGD Description
Ortholog(s) have phosphatidylinositol binding, ubiquitin binding, ubiquitin protein ligase activity


References

Huibregtse JM, et al. (1995 Mar 28). A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

Huibregtse JM, et al. (1995 May 23). A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

Hein C, et al. (1995 Oct). NPl1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin-protein ligase.

Yashiroda H, et al. (1996 Jul). Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae.

Yashiroda H, et al. (1998 Dec 28). The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions.

Wang G, et al. (1999 Jan). Functional domains of the Rsp5 ubiquitin-protein ligase.

Andoh T, et al. (2002 Aug 14). PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance.

Kaida D, et al. (2003 Jul 11). Rsp5-Bul1/2 complex is necessary for the HSE-mediated gene expression in budding yeast.

Abe F, et al. (2003 Nov). Pressure-induced differential regulation of the two tryptophan permeases Tat1 and Tat2 by ubiquitin ligase Rsp5 and its binding proteins, Bul1 and Bul2.

Boase NA, et al. (2004 Aug). A role for creD, a carbon catabolite repression gene from Aspergillus nidulans, in ubiquitination.

Bowers K, et al. (2004 Mar). Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

Pizzirusso M, et al. (2004 May). Ubiquitin-mediated targeting of a mutant plasma membrane ATPase, Pma1-7, to the endosomal/vacuolar system in yeast.

Crespo JL, et al. (2004 Sep 3). NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae.

Kee Y, et al. (2005 Jul 6). The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme.

Feller A, et al. (2006 Sep 29). Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.

Imai K, et al. (2007 Jan). Peculiar protein-protein interactions of the novel endoplasmic reticulum membrane protein Rcr1 and ubiquitin ligase Rsp5.

Ren J, et al. (2007 Jan). Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Gournas C, et al. (2010 Jan). Transport-dependent endocytosis and turnover of a uric acid-xanthine permease.

Kim HC, et al. (2011 Apr). Structure and function of a HECT domain ubiquitin-binding site.

Kaminska J, et al. (2011 Dec). Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Karachaliou M, et al. (2013 Apr). The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG04419
EOG8VT4C1

sce:TOM1

Genes: 35

SGD Description
E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase


PomBase Description
HECT-type ubiquitin ligase E3 Ptr1


AspGD Description
Ortholog(s) have role in mRNA export from nucleus and nucleus localization


References

Azad AK, et al. (1997 May). Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe.

Saleh A, et al. (1998 Oct 9). TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes.

Utsugi T, et al. (1999 Jul 8). Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures.

Sasaki T, et al. (2000 Jan). Extragenic suppressors that rescue defects in the heat stress response of the budding yeast mutant tom1.

Duncan K, et al. (2000 Jun 15). A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport.

Sasaki T, et al. (2000 Nov). Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus.

Tabb AL, et al. (2001 Mar). Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis.

Andoh T, et al. (2004 May 14). The fission yeast ptr1+ gene involved in nuclear mRNA export encodes a putative ubiquitin ligase.

Vogl C, et al. (2008 Mar 21). Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe.

Iida T, et al. (2012 Oct 12). RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast.

Sugiyama T, et al. (2013 Jul). Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Iida N, et al. (2014 Jun). Mudi, a web tool for identifying mutations by bioinformatics analysis of whole-genome sequence.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 27 genes with posterior transmembrane prediction > 50%

FOG04420
EOG8VT4C1

sce:absent

Genes: 1

PomBase Description
HECT-type ubiquitin-protein ligase E3 Pub2

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%