FOG04307
EOG8XKSQ0

sce:HSM3

Genes: 16

SGD Description
Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation


References

Fedorova IV, et al. (1998 Mar). The yeast HSM3 gene acts in one of the mismatch repair pathways.

Fedorova IV, et al. (2000 Jan). The yeast HSM3 gene is involved in DNA mismatch repair in slowly dividing cells.

Merker JD, et al. (2000 Jan). The yeast HSM3 gene is not involved in DNA mismatch repair in rapidly dividing cells.

Fedorova IV, et al. (2004 Oct 4). Requirement of HSM3 gene for spontaneous mutagenesis in Saccharomyces cerevisiae.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Le Tallec B, et al. (2009 Feb 13). Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasome.

Park S, et al. (2009 Jun 11). Hexameric assembly of the proteasomal ATPases is templated through their C termini.

Roelofs J, et al. (2009 Jun 11). Chaperone-mediated pathway of proteasome regulatory particle assembly.

Funakoshi M, et al. (2009 May 29). Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%