FOG04018
EOG8FFBKK

sce:CIA1

Genes: 35

SGD Description
Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein


AspGD Description
Ortholog(s) have role in iron-sulfur cluster assembly, tRNA wobble uridine modification and cytosol, nucleus localization


References

Balk J, et al. (2005 Dec). The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly.

Srinivasan V, et al. (2007 Oct). Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG04019
EOG8FFBKK

sce:NBP35

Genes: 33

SGD Description
Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases


PomBase Description
iron-sulfur cluster assembly ATPase Nbp35 (predicted)


AspGD Description
Ortholog(s) have 4 iron, 4 sulfur cluster binding, ATPase activity, iron ion binding activity, role in iron-sulfur cluster assembly, tRNA wobble uridine modification and Nbp35-Cfd1 ATPase complex, cytosol, nucleus localization


References

Vitale G, et al. (1996 Oct 31). NBP35 encodes an essential and evolutionary conserved protein in Saccharomyces cerevisiae with homology to a superfamily of bacterial ATPases.

Wong S, et al. (2003). Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata.

Balk J, et al. (2005 Feb). Nar1p, a conserved eukaryotic protein with similarity to Fe-only hydrogenases, functions in cytosolic iron-sulphur protein biogenesis.

Yarunin A, et al. (2005 Feb 9). Functional link between ribosome formation and biogenesis of iron-sulfur proteins.

Hausmann A, et al. (2005 Mar 1). The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery.

Netz DJ, et al. (2007 May). The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol.

Netz DJ, et al. (2012 Apr 6). A bridging [4Fe-4S] cluster and nucleotide binding are essential for function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur protein maturation.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG04020
EOG8FFBKK

sce:CFD1

Genes: 32

SGD Description
Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol


PomBase Description
Par A family ATPase/WD repeat iron cluster assembly fusion protein (predicted)


AspGD Description
Ortholog(s) have 4 iron, 4 sulfur cluster binding, ATPase activity, role in iron-sulfur cluster assembly, tRNA wobble uridine modification and Nbp35-Cfd1 ATPase complex, cytoplasm localization


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Roy A, et al. (2003 Sep 15). A novel eukaryotic factor for cytosolic Fe-S cluster assembly.

Yarunin A, et al. (2005 Feb 9). Functional link between ribosome formation and biogenesis of iron-sulfur proteins.

Netz DJ, et al. (2007 May). The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol.

Netz DJ, et al. (2012 Apr 6). A bridging [4Fe-4S] cluster and nucleotide binding are essential for function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur protein maturation.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG04021
EOG8FFBKK

sce:absent

Genes: 26

PomBase Description
Endoplasmic Reticulum metallopeptidase Erm1 (predicted)


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN7525, A. fumigatus Af293 : Afu6g09810, A. oryzae RIB40 : AO090001000614, Aspergillus wentii : Aspwe1_0045811 and Aspergillus sydowii : Aspsy1_0045889


References

Bych K, et al. (2008 Jun 18). The iron-sulphur protein Ind1 is required for effective complex I assembly.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%