FOG04014
EOG8FFBKQ

sce:SAK1

Genes: 29

SGD Description
Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal groth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication


PomBase Description
Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1


References

Matsusaka T, et al. (1995 Jul 17). A novel protein kinase gene ssp1+ is required for alteration of growth polarity and actin localization in fission yeast.

Toda T, et al. (1996 Sep). The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

Hunter T, et al. (1997 Jan). The protein kinases of budding yeast: six score and more.

Hovland PG, et al. (1997 Sep). Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations.

Rupes I, et al. (1999 May). Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast.

Sawin KE, et al. (1999 Nov 18). Mis-specification of cortical identity in a fission yeast PAK mutant.

Sutherland CM, et al. (2003 Aug 5). Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex.

Hong SP, et al. (2003 Jul 22). Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.

Nath N, et al. (2003 Jun). Yeast Pak1 kinase associates with and activates Snf1.

Hedbacker K, et al. (2004 Sep). Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase.

McCartney RR, et al. (2005 Jun). Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Rubenstein EM, et al. (2006 Apr). Regulatory domains of Snf1-activating kinases determine pathway specificity.

Elbing K, et al. (2006 Feb 1). Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae.

Elbing K, et al. (2006 Sep 8). Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Hong SP, et al. (2007 Jun 8). Regulation of snf1 protein kinase in response to environmental stress.

Oki M, et al. (2007 Oct 1). Identification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Thorsen M, et al. (2009 Mar 12). Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae.

Hanyu Y, et al. (2009 May). Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Sajiki K, et al. (2009 May 1). Genetic control of cellular quiescence in S. pombe.

Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.

Orlova M, et al. (2010 Jan). Roles of the Snf1-activating kinases during nitrogen limitation and pseudohyphal differentiation in Saccharomyces cerevisiae.

Amorim MJ, et al. (2010 Jun 8). Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Yanagida M, et al. (2011 Dec 27). Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases.

Liu Y, et al. (2011 Mar). Interaction of SNF1 protein kinase with its activating kinase Sak1.

Valbuena N, et al. (2012 Jun 1). AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Kovacikova I, et al. (2013 Feb 15). A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Deng L, et al. (2014 Feb 17). Dueling kinases regulate cell size at division through the SAD kinase Cdr2.

Freitag SI, et al. (2014 Jan 22). Genetic and physical interaction of Ssp1 CaMKK and Rad24 14-3-3 during low pH and osmotic stress in fission yeast.

Cisneros-Barroso E, et al. (2014 Sep). Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast.

Gómez-Hierro A, et al. (2015). Ssp1 CaMKK: A Sensor of Actin Polarization That Controls Mitotic Commitment through Srk1 in Schizosaccharomyces pombe.

Davie E, et al. (2015 Feb 16). Nitrogen regulates AMPK to control TORC1 signaling.

Saitoh S, et al. (2015 Jan 15). Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 15 genes with posterior transmembrane prediction > 50%

FOG04015
EOG8FFBKQ
EOG8TTF2B

sce:TOS3

Genes: 12

SGD Description
Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog, SAK1, that arose from the whole genome duplication


PomBase Description
calmodulin-dependent kinase kinase 2


AspGD Description
Ortholog(s) have calmodulin-dependent protein kinase activity, role in negative regulation of calcineurin-NFAT signaling cascade, protein phosphorylation, regulation of nuclear division and cytosol, nucleus localization


References

Joseph JD, et al. (2000 Dec 8). Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.

Zhu H, et al. (2000 Nov). Analysis of yeast protein kinases using protein chips.

Sutherland CM, et al. (2003 Aug 5). Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex.

Hong SP, et al. (2003 Jul 22). Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.

Nath N, et al. (2003 Jun). Yeast Pak1 kinase associates with and activates Snf1.

Hedbacker K, et al. (2004 Sep). Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase.

Bimbó A, et al. (2005 Apr). Systematic deletion analysis of fission yeast protein kinases.

Webb CJ, et al. (2005 Feb). Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.

Woods A, et al. (2005 Jul). Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

McCartney RR, et al. (2005 Jun). Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases.

Kim MD, et al. (2005 May). Role of Tos3, a Snf1 protein kinase kinase, during growth of Saccharomyces cerevisiae on nonfermentable carbon sources.

Rubenstein EM, et al. (2006 Apr). Regulatory domains of Snf1-activating kinases determine pathway specificity.

Elbing K, et al. (2006 Feb 1). Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae.

Momcilovic M, et al. (2006 Sep 1). Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro.

Hong SP, et al. (2007 Jun 8). Regulation of snf1 protein kinase in response to environmental stress.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Cisneros-Barroso E, et al. (2014 Sep). Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast.

Davie E, et al. (2015 Feb 16). Nitrogen regulates AMPK to control TORC1 signaling.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG04016
EOG8FFBKQ

sce:absent

Genes: 8

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04017
EOG8FFBKQ

sce:absent

Genes: 3

AspGD Description
Ortholog(s) have role in conidiophore development, hyphal growth

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%