FOG03959
EOG8KKWKT
sce:SPT3
Genes: 33
EOG8KKWKT
sce:SPT3
Genes: 33
SGD Description
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; relocalizes to the cytosol in response to hypoxia
PomBase Description
SAGA complex subunit Spt3
AspGD Description
Ortholog(s) have transcription cofactor activity
References
Winston F, et al. (1986 Sep 11). Analysis of the yeast SPT3 gene and identification of its product, a positive regulator of Ty transcription.
Grant PA, et al. (1998 Jul 10). A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.
Madison JM, et al. (1998 Mar 30). Identification and analysis of homologues of Saccharomyces cerevisiae Spt3 suggest conserved functional domains.
Grant PA, et al. (1999 Feb 26). Expanded lysine acetylation specificity of Gcn5 in native complexes.
Dudley AM, et al. (1999 Nov 15). The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo.
Belotserkovskaya R, et al. (2000 Jan). Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters.
Larschan E, et al. (2001 Aug 1). The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.
Pray-Grant MG, et al. (2002 Dec). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.
Bhaumik SR, et al. (2002 Nov). Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo.
Sterner DE, et al. (2002 Sep 3). SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.
Leh-Louis V, et al. (2004). Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny.
Wu PY, et al. (2004 Jul 23). Molecular architecture of the S. cerevisiae SAGA complex.
Pray-Grant MG, et al. (2005 Jan 27). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.
Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.
Helmlinger D, et al. (2008 Nov 15). The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Helmlinger D, et al. (2011 Jun 3). Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
Georgakopoulos P, et al. (2012 Nov). SAGA complex components and acetate repression in Aspergillus nidulans.
Georgakopoulos P, et al. (2013). The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex in Aspergillus nidulans.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Wang J, et al. (2014 Oct). Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03960
EOG8KKWKT
sce:TAF13
Genes: 24
EOG8KKWKT
sce:TAF13
Genes: 24
SGD Description
TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
PomBase Description
transcription factor TFIID complex subunit Taf13 (predicted)
AspGD Description
Ortholog(s) have role in RNA polymerase II transcriptional preinitiation complex assembly, cellular response to drug and transcription factor TFIID complex localization
References
Dubois E, et al. (1987). Characterization of two new genes essential for vegetative growth in Saccharomyces cerevisiae: nucleotide sequence determination and chromosome mapping.
Birck C, et al. (1998 Jul 24). Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.
Sanders SL, et al. (2000 May 5). Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex.
Gangloff YG, et al. (2001 Apr). The histone fold is a key structural motif of transcription factor TFIID.
Sanders SL, et al. (2002 Aug). Molecular characterization of Saccharomyces cerevisiae TFIID.
Martinez E, et al. (2002 Dec). Multi-protein complexes in eukaryotic gene transcription.
Leurent C, et al. (2002 Jul 1). Mapping histone fold TAFs within yeast TFIID.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03961
EOG8KKWKT
sce:absent
Genes: 5
EOG8KKWKT
sce:absent
Genes: 5
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03962
EOG8KKWKT
sce:absent
Genes: 2
EOG8KKWKT
sce:absent
Genes: 2
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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