FOG03840
EOG8RJDGG
EOG8XD297

sce:AVO1

Genes: 27

SGD Description
Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth


PomBase Description
stress activated MAP kinase interacting protein Sin1


AspGD Description
Protein required for polarization of actin at hyphal tips; complementation analyses with S. cerevisiae shows functional equivalence with the TORC2 component Avo1p


References

Wilkinson MG, et al. (1999 Aug 2). Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.

Ikebe C, et al. (2002 Feb 8). Isolation and characterization of a novel F-box protein Pof10 in fission yeast.

Loewith R, et al. (2002 Sep). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.

Wedaman KP, et al. (2003 Mar). Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.

Wullschleger S, et al. (2005 Sep 2). Molecular organization of target of rapamycin complex 2.

Matsuo T, et al. (2007 Apr). Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Hayashi T, et al. (2007 Dec). Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.

Kanoh J, et al. (2007 Dec). Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?

Bates S, et al. (2007 Jun). Candida albicans Iff11, a secreted protein required for cell wall structure and virulence.

Ikeda K, et al. (2008 Feb 1). Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.

Schonbrun M, et al. (2009 Aug). TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.

Hartmuth S, et al. (2009 Jun 1). Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Tatebe H, et al. (2010 Nov 23). Rab-family GTPase regulates TOR complex 2 signaling in fission yeast.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Ikai N, et al. (2011 Nov). The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.

Boisramé A, et al. (2011 Oct). Unexpected role for a serine/threonine-rich domain in the Candida albicans Iff protein family.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Schonbrun M, et al. (2013 Jul 5). TORC2 is required to maintain genome stability during S phase in fission yeast.

She X, et al. (2013 Sep). Cell surface changes in the Candida albicans mitochondrial mutant goa1Δ are associated with reduced recognition by innate immune cells.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Laor D, et al. (2014 Mar). Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Hatano T, et al. (2015). Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose.

Baker K, et al. (2016 Jul 1). TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Tatebe H, et al. (2017 Mar 7). Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%