FOG03839
EOG8RN8VH

sce:DAD2

Genes: 22

SGD Description
Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis


PomBase Description
DASH complex subunit Dad2


AspGD Description
Ortholog(s) have DASH complex, cytosol, mitotic spindle midzone, mitotic spindle pole body localization


References

Aiba H, et al. (1998 Oct). Isolation and characterization of high-osmolarity-sensitive mutants of fission yeast.

Nakamichi N, et al. (2000 Nov). Identification and characterization of a novel gene, hos2+, the function of which is necessary for growth under high osmotic stress in fission yeast.

Li Y, et al. (2002 Jan 15). The mitotic spindle is required for loading of the DASH complex onto the kinetochore.

Liu X, et al. (2005 Aug 17). Molecular analysis of kinetochore architecture in fission yeast.

Miranda JJ, et al. (2005 Feb). The yeast DASH complex forms closed rings on microtubules.

Westermann S, et al. (2005 Jan 21). Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.

Joglekar AP, et al. (2006 Jun). Molecular architecture of a kinetochore-microtubule attachment site.

Asbury CL, et al. (2006 Jun 27). The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement.

Westermann S, et al. (2006 Mar 23). The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.

Kobayashi Y, et al. (2007 Mar). The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Saitoh S, et al. (2008 Sep). Dual regulation of Mad2 localization on kinetochores by Bub1 and Dam1/DASH that ensure proper spindle interaction.

Calvo IA, et al. (2009 Aug 12). Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Gao Q, et al. (2010 Jul 27). A non-ring-like form of the Dam1 complex modulates microtubule dynamics in fission yeast.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Hou H, et al. (2012 Nov 26). Csi1 links centromeres to the nuclear envelope for centromere clustering.

Chen Z, et al. (2012 Oct). A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Tay Z, et al. (2013). Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Nguyen TT, et al. (2015 Feb 11). Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.

Tang MY, et al. (2015 May 10). Two fission yeast high mobility group box proteins in the maintenance of genomic integrity following doxorubicin insult.

Nguyen TT, et al. (2016 Jan 21). Predicting chemotherapeutic drug combinations through gene network profiling.

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%