FOG03564
EOG8F4QWC
sce:NSP1
Genes: 27
EOG8F4QWC
sce:NSP1
Genes: 27
SGD Description
FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)
PomBase Description
nucleoporin Nsp1
AspGD Description
Ortholog(s) have nuclear periphery localization
References
Hurt EC, et al. (1988 Dec 20). A novel nucleoskeletal-like protein located at the nuclear periphery is required for the life cycle of Saccharomyces cerevisiae.
Nehrbass U, et al. (1990 Jun 15). NSP1: a yeast nuclear envelope protein localized at the nuclear pores exerts its essential function by its carboxy-terminal domain.
Schlaich NL, et al. (1997 Jan). In vitro reconstitution of a heterotrimeric nucleoporin complex consisting of recombinant Nsp1p, Nup49p, and Nup57p.
Belgareh N, et al. (1998 Dec). Functional characterization of a Nup159p-containing nuclear pore subcomplex.
Stochaj U, et al. (1998 Feb 15). The small GTPase Gsp1p binds to the repeat domain of the nucleoporin Nsp1p.
Hellmuth K, et al. (1998 Nov). Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.
Seedorf M, et al. (1999 Feb). Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase.
Strässer K, et al. (2000 Aug 21). Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export.
Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.
Quimby BB, et al. (2000 Sep 15). The mechanism of ran import into the nucleus by nuclear transport factor 2.
Allen NP, et al. (2001 Aug 3). Proteomic analysis of nucleoporin interacting proteins.
Bailer SM, et al. (2001 Dec). The Nsp1p carboxy-terminal domain is organized into functionally distinct coiled-coil regions required for assembly of nucleoporin subcomplexes and nucleocytoplasmic transport.
Gleizes PE, et al. (2001 Dec 10). Ultrastructural localization of rRNA shows defective nuclear export of preribosomes in mutants of the Nup82p complex.
Grosshans H, et al. (2001 May 14). Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.
Bayliss R, et al. (2002 Dec 27). GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta.
Suntharalingam M, et al. (2003 Jun). Peering through the pore: nuclear pore complex structure, assembly, and function.
Denning DP, et al. (2003 Mar 4). Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.
Strawn LA, et al. (2004 Mar). Minimal nuclear pore complexes define FG repeat domains essential for transport.
De Souza CP, et al. (2004 Nov 23). Partial nuclear pore complex disassembly during closed mitosis in Aspergillus nidulans.
Osmani AH, et al. (2006 Dec). Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03565
EOG8B5MM7
EOG8F4QWC
EOG8WSTS4
sce:NUP82
Genes: 16
EOG8B5MM7
EOG8F4QWC
EOG8WSTS4
sce:NUP82
Genes: 16
SGD Description
Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p); relocalizes to the cytosol in response to hypoxia
PomBase Description
nucleoporin Nup82
References
Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).
Grandi P, et al. (1995 Sep). A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p.
Hurwitz ME, et al. (1995 Sep). NUP82 is an essential yeast nucleoporin required for poly(A)+ RNA export.
Belgareh N, et al. (1998 Dec). Functional characterization of a Nup159p-containing nuclear pore subcomplex.
Ho AK, et al. (2000 Aug). Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p.
Bailer SM, et al. (2000 Aug 4). Nup116p associates with the Nup82p-Nsp1p-Nup159p nucleoporin complex.
Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.
Bailer SM, et al. (2001 Dec). The Nsp1p carboxy-terminal domain is organized into functionally distinct coiled-coil regions required for assembly of nucleoporin subcomplexes and nucleocytoplasmic transport.
Gleizes PE, et al. (2001 Dec 10). Ultrastructural localization of rRNA shows defective nuclear export of preribosomes in mutants of the Nup82p complex.
Suntharalingam M, et al. (2003 Jun). Peering through the pore: nuclear pore complex structure, assembly, and function.
Yoshida K, et al. (2011 Oct 4). Structural and functional analysis of an essential nucleoporin heterotrimer on the cytoplasmic face of the nuclear pore complex.
Stuwe T, et al. (2012 Jun 22). Molecular basis for the anchoring of proto-oncoprotein Nup98 to the cytoplasmic face of the nuclear pore complex.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03566
EOG8F4QWC
EOG8WPZK4
sce:NUP1
Genes: 11
EOG8F4QWC
EOG8WPZK4
sce:NUP1
Genes: 11
SGD Description
FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
References
Davis LI, et al. (1990 Jun 15). The NUP1 gene encodes an essential component of the yeast nuclear pore complex.
Titov AA, et al. (1999 Oct 18). The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus.
Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.
Solsbacher J, et al. (2000 Nov). Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha.
Allen NP, et al. (2001 Aug 3). Proteomic analysis of nucleoporin interacting proteins.
Denning D, et al. (2001 Sep 3). The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex.
Allen NP, et al. (2002 Dec). Deciphering networks of protein interactions at the nuclear pore complex.
Bayliss R, et al. (2002 Dec 27). GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta.
Gilchrist D, et al. (2002 May 17). Accelerating the rate of disassembly of karyopherin.cargo complexes.
Suntharalingam M, et al. (2003 Jun). Peering through the pore: nuclear pore complex structure, assembly, and function.
Denning DP, et al. (2003 Mar 4). Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.
Ubersax JA, et al. (2003 Oct 23). Targets of the cyclin-dependent kinase Cdk1.
Pyhtila B, et al. (2003 Oct 24). A gradient of affinity for the karyopherin Kap95p along the yeast nuclear pore complex.
Strawn LA, et al. (2004 Mar). Minimal nuclear pore complexes define FG repeat domains essential for transport.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03567
EOG8WSTS4
sce:absent
Genes: 4
EOG8WSTS4
sce:absent
Genes: 4
AspGD Description
Ortholog(s) have nuclear pore localization
References
Osmani AH, et al. (2006 Dec). Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03568
EOG8F4QWC
sce:absent
Genes: 4
EOG8F4QWC
sce:absent
Genes: 4
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03569
EOG8F4QWC
sce:absent
Genes: 2
EOG8F4QWC
sce:absent
Genes: 2
PomBase Description
Schizosaccharomyces specific protein Mug68|nucleoporin Nup124
References
Balasundaram D, et al. (1999 Aug). Nup124p is a nuclear pore factor of Schizosaccharomyces pombe that is important for nuclear import and activity of retrotransposon Tf1.
Varadarajan P, et al. (2005 Apr). The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr.
Sistla S, et al. (2007 Sep). Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Asakawa H, et al. (2010 Nov 9). Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Zhang L, et al. (2013). Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.
Sugiyama T, et al. (2013 Jul). Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.
Asakawa H, et al. (2014 Mar-Apr). Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.
Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.
Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
