FOG03559
EOG8FFBJ6

sce:PPH21;PPH22

Genes: 39

SGD Description
Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication|Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication


PomBase Description
minor serine/threonine protein phosphatase Ppa1|serine/threonine protein phosphatase Ppa2


AspGD Description
Ortholog(s) have protein serine/threonine phosphatase activity|Ortholog(s) have phosphoprotein phosphatase activity, role in hyphal growth, negative regulation of G2/M transition of mitotic cell cycle, protein dephosphorylation and cytosol, nucleus localization


References

Sneddon AA, et al. (1990 Dec). Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes.

Kinoshita N, et al. (1990 Oct 19). Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle.

Sutton A, et al. (1991 Apr). The SIT4 protein phosphatase functions in late G1 for progression into S phase.

Kinoshita N, et al. (1991 Dec). The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control.

Warbrick E, et al. (1991 Dec). The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

Ronne H, et al. (1991 Oct). Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis.

Kinoshita N, et al. (1993 Jun). Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

Shimanuki M, et al. (1993 Mar). Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosis.

Yoshida T, et al. (1994 Jul). A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning.

Verhasselt P, et al. (1995 Aug). New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae.

Kinoshita K, et al. (1996 Jan). The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis.

Wu J, et al. (2000 Nov 1). Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo.

Kosmidou E, et al. (2001 Feb). A type 2A protein phosphatase gene from Aspergillus nidulans is involved in hyphal morphogenesis.

Tanabe O, et al. (2001 May). Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin.

Kalhor HR, et al. (2001 Nov 15). Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast.

Wang H, et al. (2003 Nov). Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Zheng Y, et al. (2005 Apr). The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes.

Pardo M, et al. (2005 Apr 15). The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.

Fenyvuesvolgyi C, et al. (2005 Dec 15). Fission yeast homologue of Tip41-like proteins regulates type 2A phosphatases and responses to nitrogen sources.

Van Hoof C, et al. (2005 Feb 15). Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.

Riedel CG, et al. (2006 May 4). Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Son S, et al. (2009 Apr). Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1.

Hanyu Y, et al. (2009 May). Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Bernal M, et al. (2012). Regulation of fission yeast morphogenesis by PP2A activator pta2.

Goyal A, et al. (2012 Apr). Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Buttrick GJ, et al. (2012 Apr 1). Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.

Navarro FJ, et al. (2012 May 24). A systematic screen reveals new elements acting at the G2/M cell cycle control.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Chica N, et al. (2016 Feb 8). Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Nie M, et al. (2016 Jul). Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.

Moris N, et al. (2016 Nov 16). A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03560
EOG8FFBJ6

sce:SIT4

Genes: 31

SGD Description
Type 2A-related serine-threonine phosphatase; functions in the G1/S transition of the mitotic cycle; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6


PomBase Description
serine/threonine protein phosphatase Ppe1


AspGD Description
Ortholog(s) have protein serine/threonine phosphatase activity


References

Arndt KT, et al. (1989 Feb 24). A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases.

Sutton A, et al. (1991 Apr). The SIT4 protein phosphatase functions in late G1 for progression into S phase.

Düvel K, et al. (2003 Jun). Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast.

Wang H, et al. (2003 Nov). Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases.

Lee CM, et al. (2004 Feb). The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans.

Zheng Y, et al. (2005 Apr). The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes.

Van Hoof C, et al. (2005 Feb 15). Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.

Fitzgibbon GJ, et al. (2005 Sep). Genetic analysis of the TOR pathway in Aspergillus nidulans.

Son S, et al. (2009 Apr). Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1.

Zacchi LF, et al. (2010 Jul). Mds3 regulates morphogenesis in Candida albicans through the TOR pathway.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03561
EOG8FFBJ6

sce:PPG1

Genes: 31

SGD Description
Putative serine/threonine protein phosphatase; putative phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases


PomBase Description
protein phosphatase type 2A Ppa1


AspGD Description
Ortholog(s) have role in asymmetric protein localization to old mitotic spindle pole body, glycogen metabolic process, negative regulation of septation initiation signaling, syncytium formation by plasma membrane fusion


References

Posas F, et al. (1993 Jan 15). The gene PPG encodes a novel yeast protein phosphatase involved in glycogen accumulation.

Wang H, et al. (2003 Nov). Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases.

Van Hoof C, et al. (2005 Feb 15). Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.

Hanaoka N, et al. (2008 Oct). Identification of the putative protein phosphatase gene PTC1 as a virulence-related gene using a silkworm model of Candida albicans infection.

Noble SM, et al. (2010 Jul). Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.

Albataineh MT, et al. (2014 Dec). Ppg1, a PP2A-type protein phosphatase, controls filament extension and virulence in Candida albicans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03562
EOG8FFBJ6

sce:PPH3

Genes: 28

SGD Description
Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes


PomBase Description
serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted)


AspGD Description
Ortholog(s) have role in protein dephosphorylation, regulation of circadian rhythm and cytosol, nucleus localization


References

Ronne H, et al. (1991 Oct). Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis.

Hoffmann R, et al. (1994 May). The Saccharomyces cerevisiae gene PPH3 encodes a protein phosphatase with properties different from PPX, PP1 and PP2A.

Bertram PG, et al. (2000 Nov 17). Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases.

Wang H, et al. (2003 Nov). Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases.

Van Hoof C, et al. (2005 Feb 15). Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.

Gingras AC, et al. (2005 Nov). A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.

Keogh MC, et al. (2006 Jan 26). A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Birot A, et al. (2017 May 15). A second Wpl1 anti-cohesion pathway requires dephosphorylation of fission yeast kleisin Rad21 by PP4.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03563
EOG8FFBJ6

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%