FOG03525
EOG8MW6QG
sce:GRX2
Genes: 40
EOG8MW6QG
sce:GRX2
Genes: 40
SGD Description
Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form translocated to the mitochondrial matrix; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
PomBase Description
glutaredoxin Grx1|glutaredoxin Grx2
AspGD Description
Ortholog(s) have glutathione disulfide oxidoreductase activity, glutathione peroxidase activity, glutathione transferase activity and role in glutathione metabolic process, removal of superoxide radicals
References
Gan ZR, et al. (1990 May 16). Complete amino acid sequence of yeast thioltransferase (glutaredoxin).
Gan ZR, et al. (1992 Sep 16). Cloning and sequencing of a gene encoding yeast thioltransferase.
Luikenhuis S, et al. (1998 May). The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species.
Kim HG, et al. (1999 Dec 31). Cloning, nucleotide sequence and expression of thioltransferase (glutaredoxin) cDNA from Schizosaccharomyces pombe.
Cho YW, et al. (2000 Dec 15). Cloning, expression and regulation of Schizosaccharomyces pombe gene encoding thioltransferase.
Grant CM, et al. (2000 Jan 31). Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae.
Lim CJ, et al. (2002 Dec 31). Pap1-dependent regulation of the GSTII gene from the fission yeast.
Kim M, et al. (2002 Jul 31). Transcription of Schizosaccharomyces pombe thioltransferase-1 in response to stress conditions.
Pedrajas JR, et al. (2002 Jun 15). Two isoforms of Saccharomyces cerevisiae glutaredoxin 2 are expressed in vivo and localize to different subcellular compartments.
Collinson EJ, et al. (2002 May 10). The yeast glutaredoxins are active as glutathione peroxidases.
Lim CJ, et al. (2003 Aug 31). The thioltransferase (glutaredoxin) 1 gene of fission yeast is regulated by Atf1 and Pap1.
Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.
Collinson EJ, et al. (2003 Jun 20). Role of yeast glutaredoxins as glutathione S-transferases.
Chung WH, et al. (2004 Sep 3). Differential expression and role of two dithiol glutaredoxins Grx1 and Grx2 in Schizosaccharomyces pombe.
Kim HG, et al. (2005 Mar). Carbon source-dependent regulation of a second gene encoding glutaredoxin from the fission yeast Schizosaccharomyces pombe.
Chung WH, et al. (2005 May 6). Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe.
Discola KF, et al. (2009 Jan 23). Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae.
Kim KD, et al. (2010 Feb 12). Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.
Li WF, et al. (2010 Jul). Structural basis for the different activities of yeast Grx1 and Grx2.
Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.
García-Santamarina S, et al. (2013 Dec). Methionine sulphoxide reductases revisited: free methionine as a primary target of H₂O₂stress in auxotrophic fission yeast.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Zhou H, et al. (2015 Oct). Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.
Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Boronat S, et al. (2017 Jun). Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.
Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.
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| Phobius transmembrane predictions
4 genes with posterior transmembrane prediction > 50% |
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FOG03526
EOG8MW6QG
sce:GRX7;GRX6
Genes: 33
EOG8MW6QG
sce:GRX7;GRX6
Genes: 33
SGD Description
Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication|Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
PomBase Description
monothiol glutaredoxin Grx3
AspGD Description
Ortholog(s) have glutathione-disulfide reductase activity, protein homodimerization activity and role in cellular response to oxidative stress
References
Moon JS, et al. (2005 Aug 31). Characterization and regulation of the gene encoding monothiol glutaredoxin 3 in the fission yeast Schizosaccharomyces pombe.
Chung WH, et al. (2005 May 6). Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe.
Lee JH, et al. (2007 Dec 31). Expression, characterization and regulation of a Saccharomyces cerevisiae monothiol glutaredoxin (Grx6) gene in Schizosaccharomyces pombe.
Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
7 genes with posterior transmembrane prediction > 50% |
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FOG03527
EOG8MW6QG
sce:PRM4
Genes: 4
EOG8MW6QG
sce:PRM4
Genes: 4
SGD Description
Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
References
Heiman MG, et al. (2000 Oct 30). Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG03528
EOG8MW6QG
sce:absent
Genes: 2
EOG8MW6QG
sce:absent
Genes: 2
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG03529
EOG8MW6QG
sce:GRX1
Genes: 3
EOG8MW6QG
sce:GRX1
Genes: 3
SGD Description
Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
References
Luikenhuis S, et al. (1998 May). The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species.
Grant CM, et al. (2000 Jan 31). Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae.
Collinson EJ, et al. (2002 May 10). The yeast glutaredoxins are active as glutathione peroxidases.
Collinson EJ, et al. (2003 Jun 20). Role of yeast glutaredoxins as glutathione S-transferases.
Håkansson KO, et al. (2007 Mar). Structure of glutaredoxin Grx1p C30S mutant from yeast.
Yu J, et al. (2008 Aug 15). Glutathionylation-triggered conformational changes of glutaredoxin Grx1 from the yeast Saccharomyces cerevisiae.
Discola KF, et al. (2009 Jan 23). Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae.
Li WF, et al. (2010 Jul). Structural basis for the different activities of yeast Grx1 and Grx2.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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